This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sellick, G. S. Articles by Houlston, R. S. Search for Related Content PubMed PubMed Citation Articles by Sellick, G. S. Articles by Houlston, R. S.

The P2X7 Receptor Gene A1513C Polymorphism Does Not Contribute to Risk of Familial or Sporadic Chronic Lymphocytic Leukemia

¹ Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, and ² Section of Haemato-Oncology, Institute of Cancer Research, London

Requests for reprints: Richard S. Houlston, Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG. Phone: 44-208-722-4175; Fax: 44-208-722-4362. E-mail: richard.houlston{at}icr.ac.uk

The P2X7 receptor, a plasma membrane ATP-gated ion channel that plays a role in lymphocyte apoptosis, has been suggested to be involved in the development of chronic lymphocytic leukemia (CLL). P2X7 is polymorphic with 1513A and 1513C alleles encoding fully active and nonfunctional proteins, respectively. We evaluated the significance of the P2X7-A1513C polymorphism on CLL risk by genotyping 424 patients and 428 healthy controls. To empower detection of an association, we included in our analysis 106 familial cases. Allele frequencies were identical in cases and controls irrespective of whether cases were familial or sporadic (frequency of the C allele was 0.17 and 0.17, respectively). The odds ratio of CLL associated with the C allele was 1.03 (95% confidence interval: 0.80-1.31). A meta-analysis of this study and five other smaller published studies provides no evidence of relationship between this P2X7 polymorphism and risk of CLL (odds ratio = 0.99, 95% confidence interval: 0.74-1.32).

Key Words: chronic lymphocytic leukemia • P2X7 • polymorphism

This article has been cited by other articles:

				L. R. Goldin and S. L. Slager Familial CLL: Genes and Environment Hematology, January 1, 2007; 2007(1): 339 - 345. [Abstract] [Full Text] [PDF]

				G. Cabrini, S. Falzoni, S. L. Forchap, P. Pellegatti, A. Balboni, P. Agostini, A. Cuneo, G. Castoldi, O. R. Baricordi, and F. Di Virgilio A His-155 to Tyr Polymorphism Confers Gain-of-Function to the Human P2X7 Receptor of Human Leukemic Lymphocytes J. Immunol., July 1, 2005; 175(1): 82 - 89. [Abstract] [Full Text] [PDF]