CEBP Susan G. Komen for the Cure-AACR Outstanding Investigator Award for Breast Cancer Research Translational Cancer Medicine 2008: Cancer Clinical Trials and Personalized Medicine
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Cell Growth & Differentiation
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Suter, N. M.
Right arrow Articles by Ostrander, E. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Suter, N. M.
Right arrow Articles by Ostrander, E. A.
Cancer Epidemiology Biomarkers & Prevention Vol. 13, 181-189, February 2004
© 2004 American Association for Cancer Research

BRCA1 and BRCA2 Mutations in Women from Shanghai China

Nicola M. Suter1,2, Roberta M. Ray3, Yong Wei Hu4, Ming Gang Lin1, Peggy Porter1,3, Dao Li Gao4, Renata E. Zaucha1,2, Lori M. Iwasaki1,2, Leah P. Sabacan3,5, Mariela C. Langlois1,2, David B. Thomas1,2 and Elaine A. Ostrander1,2

1 Divisions of Human Biology, 2 Clinical Research, and 3 Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington; 4 The Station for Prevention and Treatment of Cancer of the Shanghai Textile, Industry Bureau, Shanghai, People’s Republic of China; and 5 Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington

Little is known about the frequency of germ-line mutations in the breast cancer susceptibility genes BRCA1 and BRCA2 among Asian populations. We investigated the distribution of BRCA1 and BRCA2 germ-line mutations and polymorphisms in a cohort of women from Shanghai, China.

Study subjects totaled 1306, and included 645 women with breast cancer, 342 women with benign breast disease, and 319 unaffected controls, born between 1924 and 1958, selected from women enrolled in a randomized trial of Breast Self-Examination in Shanghai, China. Women were selected without regard to family history of breast or ovarian cancer. All of the coding regions and exon-intron boundaries were screened. Data were analyzed with respect to age at diagnosis, and family history of breast and ovarian cancer.

The prevalence of known disease-associated mutations in women with breast cancer was 1.1% each, for BRCA1 and BRCA2. Among breast cancer cases with a family history of breast or ovarian cancer, 8.1% and 2.7% carried likely BRCA1 and BRCA2 disease-associated mutations, respectively.

Overall, these results suggest that inherited susceptibility to breast cancer due to germ-line BRCA1/2 mutations among women with a family history of breast cancer is comparable between women from Shanghai and Caucasian women of Western European descent. Most alterations observed appear unique to the Chinese population, suggesting a resource that will be useful for assessing risk among both Chinese women and United States women of Chinese descent.




This article has been cited by other articles:


Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
L. C. Sakoda, C. Blackston, J. A. Doherty, R. M. Ray, M. G. Lin, H. Stalsberg, D. L. Gao, Z. Feng, D. B. Thomas, and C. Chen
Polymorphisms in Steroid Hormone Biosynthesis Genes and Risk of Breast Cancer and Fibrocystic Breast Conditions in Chinese Women
Cancer Epidemiol. Biomarkers Prev., May 1, 2008; 17(5): 1066 - 1073.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
E. M. John, A. Miron, G. Gong, A. I. Phipps, A. Felberg, F. P. Li, D. W. West, and A. S. Whittemore
Prevalence of Pathogenic BRCA1 Mutation Carriers in 5 US Racial/Ethnic Groups
JAMA, December 26, 2007; 298(24): 2869 - 2876.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
D. Huo and O. I. Olopade
Genetic Testing in Diverse Populations: Are Researchers Doing Enough to Get Out the Correct Message?
JAMA, December 26, 2007; 298(24): 2910 - 2911.
[Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
P. Ang, I. H.K. Lim, T.-C. Lee, J.-T. Luo, D. C.T. Ong, P. H. Tan, and A. S.G. Lee
BRCA1 and BRCA2 Mutations in an Asian Clinic-based Population Detected Using a Comprehensive Strategy
Cancer Epidemiol. Biomarkers Prev., November 1, 2007; 16(11): 2276 - 2284.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
K. A. Zuhlke, J. J. Madeoy, J. Beebe-Dimmer, K. A. White, A. Griffin, E. M. Lange, S. B. Gruber, E. A. Ostrander, and K. A. Cooney
Truncating BRCA1 Mutations Are Uncommon in a Cohort of Hereditary Prostate Cancer Families with Evidence of Linkage to 17q Markers
Clin. Cancer Res., September 15, 2004; 10(18): 5975 - 5980.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
K. Yu, C. H. Lee, P. H. Tan, and P. Tan
Conservation of Breast Cancer Molecular Subtypes and Transcriptional Patterns of Tumor Progression Across Distinct Ethnic Populations
Clin. Cancer Res., August 15, 2004; 10(16): 5508 - 5517.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Cell Growth & Differentiation
Copyright © 2004 by the American Association for Cancer Research.