This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Yuan, J.-M. Articles by Yu, M. C. Search for Related Content PubMed PubMed Citation Articles by Yuan, J.-M. Articles by Yu, M. C.

Prediagnostic Levels of Serum Micronutrients in Relation to Risk of Gastric Cancer in Shanghai, China

¹ Department of Preventive Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California and Departments of ² Epidemiology and ³ Carcinogenesis, Shanghai Cancer Institute, Shanghai, People's Republic of China

Requests for reprints: Jian-Min Yuan, Department of Preventive Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, MC 9175, 1441 Eastlake Avenue, Los Angeles, CA 90033-0800. Phone: 323-865-0825; Fax: 323-865-0136. E-mail: jyuan{at}usc.edu

Data on blood levels of specific carotenoids and vitamins in relation to gastric cancer are scarce. Little is known about the relationship between prediagnostic serum levels of carotenoids other than ß-carotene and risk of gastric cancer especially in non-Western populations. Prediagnostic serum concentrations of -carotene, ß-carotene, ß-cryptoxanthin, lycopene, lutein/zeaxanthin, retinol, -tocopherol, -tocopherol, and vitamin C were determined on 191 cases and 570 matched controls within a cohort of 18,244 middle-aged or older men in Shanghai, China, with a follow-up of 12 years. High serum levels of -carotene, ß-carotene, and lycopene were significantly associated with reduced risk of developing gastric cancer (all Ps for trend 0.05); the odds ratios (95% confidence intervals) for the highest versus the lowest quartile of -carotene, ß-carotene, and lycopene were 0.38 (0.13-1.11), 0.54 (0.32-0.89), and 0.55 (0.30-1.00), respectively. Increased serum level of vitamin C was significantly associated with reduced risk of gastric cancer among men who neither smoked cigarettes over lifetime nor consumed 3 drinks of alcohol per day; the odds ratios (95% confidence intervals) for the second, third, and fourth quartile categories were 0.69 (0.28-1.70), 0.36 (0.14-0.94), and 0.39 (0.15-0.98), respectively, compared with the lowest quartile of vitamin C (P for trend = 0.02). There were no statistically significant relationships of serum levels of ß-cryptoxanthin, lutein/zeaxanthin, retinol, -tocopherol, and -tocopherol with gastric cancer risk. The present study implicates that dietary carotenes, lycopene, and vitamin C are potential chemopreventive agents for gastric cancer in humans.

This article has been cited by other articles:

				C. Pelucchi, I. Tramacere, P. Bertuccio, A. Tavani, E. Negri, and C. La Vecchia Dietary intake of selected micronutrients and gastric cancer risk: an Italian case-control study Ann. Onc., July 31, 2008; (2008) mdn536v1. [Abstract] [Full Text] [PDF]

				C. Persson, S. Sasazuki, M. Inoue, N. Kurahashi, M. Iwasaki, T. Miura, W. Ye, S. Tsugane, and for the JPHC Study Group Plasma levels of carotenoids, retinol and tocopherol and the risk of gastric cancer in Japan: a nested case-control study Carcinogenesis, May 1, 2008; 29(5): 1042 - 1048. [Abstract] [Full Text] [PDF]

				S. C Larsson, L. Bergkvist, I. Naslund, J. Rutegard, and A. Wolk Vitamin A, retinol, and carotenoids and the risk of gastric cancer: a prospective cohort study Am. J. Clinical Nutrition, February 1, 2007; 85(2): 497 - 503. [Abstract] [Full Text] [PDF]

				M. Jenab, E. Riboli, P. Ferrari, J. Sabate, N. Slimani, T. Norat, M. Friesen, A. Tjonneland, A. Olsen, K. Overvad, et al. Plasma and dietary vitamin C levels and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) Carcinogenesis, November 1, 2006; 27(11): 2250 - 2257. [Abstract] [Full Text] [PDF]

				C. Liu, R. M. Russell, and X.-D. Wang Lycopene Supplementation Prevents Smoke-Induced Changes in p53, p53 Phosphorylation, Cell Proliferation, and Apoptosis in the Gastric Mucosa of Ferrets J. Nutr., January 1, 2006; 136(1): 106 - 111. [Abstract] [Full Text] [PDF]