CEBP Infection and Cancer: Biology, Therapeutics, and Prevention Translational Cancer Medicine 2008: Cancer Clinical Trials and Personalized Medicine
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Cell Growth & Differentiation
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tworoger, S. S.
Right arrow Articles by McTiernan, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tworoger, S. S.
Right arrow Articles by McTiernan, A.
Cancer Epidemiology Biomarkers & Prevention Vol. 13, 94-101, January 2004
© 2004 American Association for Cancer Research

Association of CYP17, CYP19, CYP1B1, and COMT Polymorphisms with Serum and Urinary Sex Hormone Concentrations in Postmenopausal Women

Shelley S. Tworoger1,2, Jessica Chubak1,2, Erin J. Aiello1,3, Cornelia M. Ulrich1,2, Charlotte Atkinson1, John D. Potter1,2, Yutaka Yasui1, Patricia L. Stapleton4, Johanna W. Lampe1,2, Federico M. Farin4, Frank Z. Stanczyk5 and Anne McTiernan1,2,6

1 The Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, Seattle, Washington; 2 University of Washington, School of Public Health and Community Medicine, Department of Epidemiology, Seattle, Washington; 3 Group Health Cooperative, Center for Health Studies, Seattle, Washington; 4 University of Washington, Center for Ecogenetics and Environmental Health, Seattle, Washington; 5 University of Southern California, Keck School of Medicine, Department of Obstetrics and Gynecology, Los Angeles, California; and 6 University of Washington, School of Medicine, Department of Medicine, Seattle, Washington

Women with high circulating estrogen concentrations have an increased risk of breast cancer; thus, it is important to understand factors, including genetic variability, that influence estrogen concentrations. Several genetic polymorphisms that may influence sex hormone concentrations have been identified, including CYP17 (5'-untranslated region T->C), CYP19 [intron 4 (TTTA)n = 7–13 and a 3-bp deletion (-3)], CYP1B1 (Val432Leu), and COMT (Val108/158Met). We examined associations between these polymorphisms and serum concentrations of estrogens, androgens, and sex hormone-binding globulin and urinary concentrations of 2- and 16{alpha}-hydroxyestrone in 171 postmenopausal women, using data from the prerandomization visit of an exercise clinical trial. Participants were sedentary, not taking hormone therapy, and had a body mass index >24.0. Compared with noncarriers, women carrying two CYP19 7r(-3) alleles had 26% lower estrone (P < 0.001), 19% lower estradiol (P = 0.01), 23% lower free estradiol (P = 0.01), and 22% higher sex hormone-binding globulin concentrations (P = 0.06). Compared with noncarriers, women carrying at least one CYP19 8r allele had 20% higher estrone (P = 0.003), 18% higher estradiol (P = 0.02), and 21% higher free estradiol concentrations (P = 0.01). Women with the COMT Met/Met genotype had 28% higher 2-hydroxyestrone (P = 0.08) and 31% higher 16{alpha}-hydroxyestrone concentrations (P = 0.02), compared with Val/Val women. Few associations were found for CYP17 and CYP1B1 or with serum androgen concentrations. This study provides further evidence that genetic variation may appreciably alter sex hormone concentrations in postmenopausal women not taking hormone therapy.




This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
D. W. Bell, B. W. Brannigan, K. Matsuo, D. M. Finkelstein, R. Sordella, J. Settleman, T. Mitsudomi, and D. A. Haber
Increased Prevalence of EGFR-Mutant Lung Cancer in Women and in East Asian Populations: Analysis of Estrogen-Related Polymorphisms
Clin. Cancer Res., July 1, 2008; 14(13): 4079 - 4084.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
I. Czajka-Oraniec, W. Zgliczynski, A. Kurylowicz, M. Mikula, and J. Ostrowski
Association between gynecomastia and aromatase (CYP19) polymorphisms
Eur. J. Endocrinol., May 1, 2008; 158(5): 721 - 727.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
R. Colomer, M. Monzo, I. Tusquets, J. Rifa, J. M. Baena, A. Barnadas, L. Calvo, F. Carabantes, C. Crespo, M. Munoz, et al.
A Single-Nucleotide Polymorphism in the Aromatase Gene Is Associated with the Efficacy of the Aromatase Inhibitor Letrozole in Advanced Breast Carcinoma
Clin. Cancer Res., February 1, 2008; 14(3): 811 - 816.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
V. W. Setiawan, F. R. Schumacher, C. A. Haiman, D. O. Stram, D. Albanes, D. Altshuler, G. Berglund, J. Buring, E. E. Calle, F. Clavel-Chapelon, et al.
CYP17 Genetic Variation and Risk of Breast and Prostate Cancer from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
Cancer Epidemiol. Biomarkers Prev., November 1, 2007; 16(11): 2237 - 2246.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
R. Ramirez-Lorca, A. Grilo, M. T. Martinez-Larrad, L. Manzano, F. J. Serrano-Hernando, F. J. Moron, V. Perez-Gonzalez, J. L. Gonzalez-Sanchez, J. Fresneda, R. Fernandez-Parrilla, et al.
Sex and Body Mass Index Specific Regulation of Blood Pressure by CYP19A1 Gene Variants
Hypertension, November 1, 2007; 50(5): 884 - 890.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
P. T. Campbell, L. Edwards, J. R. McLaughlin, J. Green, H. B. Younghusband, and M. O. Woods
Cytochrome P450 17A1 and Catechol O-Methyltransferase Polymorphisms and Age at Lynch Syndrome Colon Cancer Onset in Newfoundland
Clin. Cancer Res., July 1, 2007; 13(13): 3783 - 3788.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
S. H. Olson, E. V. Bandera, and I. Orlow
Variants in Estrogen Biosynthesis Genes, Sex Steroid Hormone Levels, and Endometrial Cancer: A HuGE Review
Am. J. Epidemiol., February 1, 2007; 165(3): 235 - 245.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
V. Paracchini, S. Raimondi, I. T. Gram, D. Kang, N. A. Kocabas, V. N. Kristensen, D. Li, F. F. Parl, T. Rylander-Rudqvist, P. Soucek, et al.
Meta- and Pooled Analyses of the Cytochrome P-450 1B1 Val432Leu Polymorphism and Breast Cancer: A HuGE-GSEC Review
Am. J. Epidemiol., January 15, 2007; 165(2): 115 - 125.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
M. H. Tao, Q. Cai, W. H. Xu, N. Kataoka, W. Wen, W. Zheng, Y. B. Xiang, Z.-F. Zhang, and X. O. Shu
Cytochrome P450 1B1 and Catechol-O-Methyltransferase Genetic Polymorphisms and Endometrial Cancer Risk in Chinese Women
Cancer Epidemiol. Biomarkers Prev., December 1, 2006; 15(12): 2570 - 2573.
[Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
G. Jasienska, M. Kapiszewska, P. T. Ellison, M. Kalemba-Drozdz, I. Nenko, I. Thune, and A. Ziomkiewicz
CYP17 Genotypes Differ in Salivary 17-{beta} Estradiol Levels: A Study Based on Hormonal Profiles from Entire Menstrual Cycles.
Cancer Epidemiol. Biomarkers Prev., November 1, 2006; 15(11): 2131 - 2135.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
V. W. Setiawan, C. A. Haiman, F. Z. Stanczyk, L. Le Marchand, and B. E. Henderson
Racial/Ethnic differences in postmenopausal endogenous hormones: the multiethnic cohort study.
Cancer Epidemiol. Biomarkers Prev., October 1, 2006; 15(10): 1849 - 1855.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
R. Piller, E. Verla-Tebit, S. Wang-Gohrke, J. Linseisen, and J. Chang-Claude
CYP17 Genotype Modifies the Association between Lignan Supply and Premenopausal Breast Cancer Risk in Humans
J. Nutr., June 1, 2006; 136(6): 1596 - 1603.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
V. G. Vogel and E. Taioli
Have We Found the Ultimate Risk Factor for Breast Cancer?
J. Clin. Oncol., April 20, 2006; 24(12): 1791 - 1794.
[Full Text] [PDF]

Home page
 Mol Cancer ResHome page
T. M. Sissung, D. K. Price, A. Sparreboom, and W. D. Figg
Pharmacogenetics and Regulation of Human Cytochrome P450 1B1: Implications in Hormone-Mediated Tumor Metabolism and a Novel Target for Therapeutic Intervention
Mol. Cancer Res., March 1, 2006; 4(3): 135 - 150.
[Abstract] [Full Text] [PDF]

Home page
 Obstet GynecolHome page
K. Visvanathan, L. Gallicchio, C. Schilling, J. K. Babus, L. M. Lewis, S. R. Miller, H. Zacur, and J. A. Flaws
Cytochrome Gene Polymorphisms, Serum Estrogens, and Hot Flushes in Midlife Women
Obstet. Gynecol., December 1, 2005; 106(6): 1372 - 1381.
[Abstract] [Full Text] [PDF]

Home page
 Obstet GynecolHome page
A. Huber, C. C. Keck, L. A. Hefler, C. Schneeberger, J. C. Huber, E.-K. Bentz, and C. B. Tempfer
Ten Estrogen-Related Polymorphisms and Endometriosis: A Study of Multiple Gene-Gene Interactions
Obstet. Gynecol., November 1, 2005; 106(5): 1025 - 1031.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
C. F. Skibola, P. M. Bracci, R. A. Paynter, M. S. Forrest, L. Agana, T. Woodage, K. Guegler, M. T. Smith, and E. A. Holly
Polymorphisms and Haplotypes in the Cytochrome P450 17A1, Prolactin, and Catechol-O-Methyltransferase Genes and Non-Hodgkin Lymphoma Risk
Cancer Epidemiol. Biomarkers Prev., October 1, 2005; 14(10): 2391 - 2401.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
C. M. Small, M. Marcus, S. L. Sherman, A. K. Sullivan, A. K. Manatunga, and H. S. Feigelson
CYP17 genotype predicts serum hormone levels among pre-menopausal women
Hum. Reprod., August 1, 2005; 20(8): 2162 - 2167.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
G. Lurie, G. Maskarinec, R. Kaaks, F. Z. Stanczyk, and L. Le Marchand
Association of Genetic Polymorphisms with Serum Estrogens Measured Multiple Times During a 2-Year Period in Premenopausal Women
Cancer Epidemiol. Biomarkers Prev., June 1, 2005; 14(6): 1521 - 1527.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
H. Z. Ring, C. N. Lessov, T. Reed, R. Marcus, L. Holloway, G. E. Swan, and D. Carmelli
Heritability of Plasma Sex Hormones and Hormone Binding Globulin in Adult Male Twins
J. Clin. Endocrinol. Metab., June 1, 2005; 90(6): 3653 - 3658.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
R. C. Travis, M. Churchman, S. A. Edwards, G. Smith, P. K. Verkasalo, C. R. Wolf, H. Wolf, and T. J. Key
No Association of Polymorphisms in CYP17, CYP19, and HSD17-B1 with Plasma Estradiol Concentrations in 1,090 British Women
Cancer Epidemiol. Biomarkers Prev., December 1, 2004; 13(12): 2282 - 2284.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Cell Growth & Differentiation
Copyright © 2004 by the American Association for Cancer Research.