| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
1 Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, Michigan; 2 Department of Preventive Medicine, University of Southern California, Los Angeles, California; 3 Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio; and 4 Department of Epidemiology and Biostatistics, University of California, San Francisco, California
The X-ray repair cross-complementing group 1 (XRCC1) and xeroderma pigmentosum group D (XPD) genes are involved in base excision repair and nucleotide excision repair of DNA repair pathways, respectively. A growing body of evidence suggests that XRCC1 and XPD are important in environmentally induced cancers, and polymorphisms in both genes have been identified. To determine whether the XRCC1 (codon Arg399Gln) and XPD (codon Asp312Asn and codon Lys751Gln) polymorphisms are associated with prostate cancer susceptibility, we genotyped these polymorphisms in a primarily Caucasian sample of 506 sibships (n = 1,117) ascertained through a brother with prostate cancer. Sibships were analyzed with a Cox proportional hazards model with age at prostate cancer diagnosis as the outcome. Of the three polymorphisms investigated, only the XPD codon 312 Asn/Asn genotype had an odds ratio (OR) significantly different from one (OR, 1.61; 95% CI, 1.03–2.53). Analyses stratified by the clinical characteristics of affected brothers in the sibship did not reveal any significant heterogeneity in risk. In exploring two-way gene interactions, we found a markedly elevated risk for the combination of the XPD codon 312 Asn/Asn and XRCC1 codon 399 Gln/Gln genotypes (OR, 4.81; 95% CI, 1.66–13.97). In summary, our results suggest that the XPD codon 312 Asn allele may exert a modest positive effect on prostate cancer risk when two copies of the allele are present, and this effect is enhanced by the XRCC codon 399 Gln allele in its recessive state.
This article has been cited by other articles:
|
|
 |
|
  M. E. Zafereo, E. M. Sturgis, Z. Liu, L.-E Wang, Q. Wei, and G. Li Nucleotide excision repair core gene polymorphisms and risk of second primary malignancy in patients with index squamous cell carcinoma of the head and neck Carcinogenesis, June 1, 2009; 30(6): 997 - 1002. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Capella, G. Pera, N. Sala, A. Agudo, F. Rico, G. Del Giudicce, M. Plebani, D. Palli, H. Boeing, H B. Bueno-de-Mesquita, et al. DNA repair polymorphisms and the risk of stomach adenocarcinoma and severe chronic gastritis in the EPIC-EURGAST study Int. J. Epidemiol., December 1, 2008; 37(6): 1316 - 1325. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Wang, D. Chang, F.-l. Hu, H. Sui, B. Han, D.-d. li, and Y.-s. Zhao DNA Repair Gene XPD Polymorphisms and Cancer Risk: A Meta-analysis Based on 56 Case-Control Studies Cancer Epidemiol. Biomarkers Prev., March 1, 2008; 17(3): 507 - 517. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. D. Crew, M. D. Gammon, M. B. Terry, F. F. Zhang, L. B. Zablotska, M. Agrawal, J. Shen, C.-M. Long, S. M. Eng, S. K. Sagiv, et al. Polymorphisms in Nucleotide Excision Repair Genes, Polycyclic Aromatic Hydrocarbon-DNA Adducts, and Breast Cancer Risk Cancer Epidemiol. Biomarkers Prev., October 1, 2007; 16(10): 2033 - 2041. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Chen, A. M. Kamat, M. Huang, H.B. Grossman, C. P. Dinney, S. P. Lerner, X. Wu, and J. Gu High-order interactions among genetic polymorphisms in nucleotide excision repair pathway genes and smoking in modulating bladder cancer risk Carcinogenesis, October 1, 2007; 28(10): 2160 - 2165. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Wang, M. R. Spitz, J. J. Lee, M. Huang, S. M. Lippman, and X. Wu Nucleotide Excision Repair Pathway Genes and Oral Premalignant Lesions Clin. Cancer Res., June 15, 2007; 13(12): 3753 - 3758. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. L. Nock, M. S. Cicek, L. Li, X. Liu, B. A. Rybicki, A. Moreira, S. J. Plummer, G. Casey, and J. S. Witte Polymorphisms in estrogen bioactivation, detoxification and oxidative DNA base excision repair genes and prostate cancer risk Carcinogenesis, September 1, 2006; 27(9): 1842 - 1848. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Hung, J. Hall, P. Brennan, and P. Boffetta Genetic Polymorphisms in the Base Excision Repair Pathway and Cancer Risk: A HuGE Review Am. J. Epidemiol., November 15, 2005; 162(10): 925 - 942. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Chan, P. H. Gann, and E. L. Giovannucci Role of Diet in Prostate Cancer Development and Progression J. Clin. Oncol., November 10, 2005; 23(32): 8152 - 8160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Bigler, C. M. Ulrich, T. Kawashima, J. Whitton, and J. D. Potter DNA Repair Polymorphisms and Risk of Colorectal Adenomatous or Hyperplastic Polyps Cancer Epidemiol. Biomarkers Prev., November 1, 2005; 14(11): 2501 - 2508. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Matullo, S. Guarrera, C. Sacerdote, S. Polidoro, L. Davico, S. Gamberini, M. Karagas, G. Casetta, L. Rolle, A. Piazza, et al. Polymorphisms/Haplotypes in DNA Repair Genes and Smoking: A Bladder Cancer Case-Control Study Cancer Epidemiol. Biomarkers Prev., November 1, 2005; 14(11): 2569 - 2578. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. N. Silva, O. M. Gil, V. C. Oliveira, M. N. Cabral, A. P. Azevedo, A. Faber, I. Manita, T. C. Ferreira, E. Limbert, J. E. Pina, et al. Association of Polymorphisms in ERCC2 Gene with Non-Familial Thyroid Cancer Risk Cancer Epidemiol. Biomarkers Prev., October 1, 2005; 14(10): 2407 - 2412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Ritchey, W.-Y. Huang, A. P. Chokkalingam, Y.-T. Gao, J. Deng, P. Levine, F. Z. Stanczyk, and A. W. Hsing Genetic Variants of DNA Repair Genes and Prostate Cancer: A Population-Based Study Cancer Epidemiol. Biomarkers Prev., July 1, 2005; 14(7): 1703 - 1709. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Hu, H. Ma, F. Chen, Q. Wei, and H. Shen XRCC1 Polymorphisms and Cancer Risk: A Meta-analysis of 38 Case-Control Studies Cancer Epidemiol. Biomarkers Prev., July 1, 2005; 14(7): 1810 - 1818. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Broberg, J. Bjork, K. Paulsson, M. Hoglund, and M. Albin Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer Carcinogenesis, July 1, 2005; 26(7): 1263 - 1271. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-T. Jeon, J. W. Kim, N.-H. Park, Y.-S. Song, S.-B. Kang, and H.-P. Lee DNA repair gene XRCC1 Arg399Gln polymorphism is associated with increased risk of uterine leiomyoma Hum. Reprod., June 1, 2005; 20(6): 1586 - 1589. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Fan, T. S. Kumaravel, F. Jalali, P. Marrano, J. A. Squire, and R. G. Bristow Defective DNA Strand Break Repair after DNA Damage in Prostate Cancer Cells: Implications for Genetic Instability and Prostate Cancer Progression Cancer Res., December 1, 2004; 64(23): 8526 - 8533. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
