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Serum Insulin-Like Growth Factor-I Is Positively Associated with Serum Prostate-Specific Antigen in Middle-Aged Men without Evidence of Prostate Cancer

¹ Department of Health Sciences, University of York, and The Hull York Medical School, Heslington, York; ² Division of Surgery, University of Bristol, Bristol Royal Infirmary, Bristol; ³ Department of Social Medicine, University of Bristol, Clifton, Bristol; ⁴ Division of Primary Health Care, University of Bristol, Cotham Hill, Bristol; ⁵ Bristol Urological Institute, Southmead Hospital, Bristol; ⁶ Oncology Centre, Addenbrooke’s Hospital, Cambridge; and ⁷ Academic Urology Unit, Division of Clinical Sciences, University of Sheffield, Sheffield, United Kingdom

We have examined the relationship between serum insulin-like growth factor-I (IGF-I) and prostate-specific antigen in 367 healthy men without evidence of prostate cancer and found a positive association (P = 0.05). In men without prostate cancer, serum prostate-specific antigen is closely related to prostate size, and our findings, therefore, suggest that IGF-I may induce prostatic epithelial proliferation. Higher circulating levels of IGF-I have been associated with increased risk of both prostate cancer and possibly benign prostatic hyperplasia. Greater rates of cell proliferation induced by IGF-I may be a key biological pathway underlying these disorders.

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