This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Probst-Hensch, N. M. Articles by Yu, M. C. Search for Related Content PubMed PubMed Citation Articles by Probst-Hensch, N. M. Articles by Yu, M. C.

Determinants of Circulating Insulin-like Growth Factor I and Insulin-like Growth Factor Binding Protein 3 Concentrations in a Cohort of Singapore Men and Women¹

University Hospital Zürich, Cancer Registry Zürich, Zürich, Switzerland [N. M. P-H. N. M.]; Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, 117597 [H. W., A. S., H-P. L.]; Department of Obstetrics and Gynaecology, Faculty of Medicine, National University Hospital, Singapore 119074 [V. H. H. G.]; and University of Southern California/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033-0800 [M. C. Y.]

Variation in the circulating concentrations of the insulin-like growth factor (IGF) system has been implicated in the etiology of chronic diseases including cancer (prostate, breast, colon, and lung), heart disease, type 2 diabetes, and osteoporosis. We searched for sociodemographic, anthropometric, reproductive, lifestyle, and dietary determinants of IGF-I and insulin-like growth factor binding protein (IGFBP) -3 serum concentrations. Serum samples were collected in a Singapore Chinese cohort with a mean age of 61 years. Subject information was assessed during an in-person interview. Radioimmunometrically measured IGF-I and IGFBP-3 concentrations were available for 312 men and 326 postmenopausal women ages 50 years or older. Mean IGF-I concentrations were 144 ng/ml and 121 ng/ml for men and women, respectively (gender difference, P < 0.0001), and mean IGFBP-3 concentrations were 3710 ng/ml and 4147 ng/ml for men and women, respectively (gender difference, P < 0.0001). IGF-I and IGFBP-3 decreased with age (P for trend <0.0001); the age-related decrease in the IGF-I:IGFBP-3 molar ratio was stronger in women than men. IGF-I concentrations were higher among physically inactive subjects and among women with an early age at menarche. Consumption of saturated fat was found to decrease, and intake of -3 polyunsaturated fatty acids and of dietary fiber was found to increase circulating IGFBP-3 concentrations. Intake of calcium from food and supplement was associated positively with circulating IGF-I, IGFBP-3, and molar ratio. Intake of soy was associated positively with IGF-I and molar ratio concentrations, but only in men. The results of this study lend additional support to the hypothesis that circulating IGF-I concentrations increase the risk of prostate, bladder, colorectal, and breast cancer.

This article has been cited by other articles:

				M. Lajous, M.-C. Boutron-Ruault, A. Fabre, F. Clavel-Chapelon, and I. Romieu Carbohydrate intake, glycemic index, glycemic load, and risk of postmenopausal breast cancer in a prospective study of French women Am. J. Clinical Nutrition, May 1, 2008; 87(5): 1384 - 1391. [Abstract] [Full Text] [PDF]

				F. L Crowe, T. J Key, P. N Appleby, R. C Travis, K. Overvad, M. U Jakobsen, N. F Johnsen, A. Tjonneland, J. Linseisen, S. Rohrmann, et al. Dietary fat intake and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition Am. J. Clinical Nutrition, May 1, 2008; 87(5): 1405 - 1413. [Abstract] [Full Text] [PDF]

				J.-R. Zhou, L. Li, and W. Pan Dietary soy and tea combinations for prevention of breast and prostate cancers by targeting metabolic syndrome elements in mice Am. J. Clinical Nutrition, September 1, 2007; 86(3): 882S - 888S. [Abstract] [Full Text] [PDF]

				R J. Barnard Prostate cancer prevention by nutritional means to alleviate metabolic syndrome Am. J. Clinical Nutrition, September 1, 2007; 86(3): 889S - 893S. [Abstract] [Full Text] [PDF]

				R. M. Martin, J. M. P. Holly, G. Davey Smith, and D. Gunnell Associations of Adiposity from Childhood into Adulthood with Insulin Resistance and the Insulin-Like Growth Factor System: 65-Year Follow-Up of the Boyd Orr Cohort J. Clin. Endocrinol. Metab., September 1, 2006; 91(9): 3287 - 3295. [Abstract] [Full Text] [PDF]

				L. M. Morimoto, P. A. Newcomb, E. White, J. Bigler, and J. D. Potter Variation in Plasma Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3: Genetic Factors Cancer Epidemiol. Biomarkers Prev., June 1, 2005; 14(6): 1394 - 1401. [Abstract] [Full Text] [PDF]

				A. H Wu, F. Z Stanczyk, C. Martinez, C.-C. Tseng, S. Hendrich, P. Murphy, S. Chaikittisilpa, D. O Stram, and M. C Pike A controlled 2-mo dietary fat reduction and soy food supplementation study in postmenopausal women Am. J. Clinical Nutrition, May 1, 2005; 81(5): 1133 - 1141. [Abstract] [Full Text] [PDF]

				H.-L. Wong, K. DeLellis, N. Probst-Hensch, W.-P. Koh, D. Van Den Berg, H.-P. Lee, M. C. Yu, and S. A. Ingles A New Single Nucleotide Polymorphism in the Insulin-Like Growth Factor I Regulatory Region Associates with Colorectal Cancer Risk in Singapore Chinese Cancer Epidemiol. Biomarkers Prev., January 1, 2005; 14(1): 144 - 151. [Abstract] [Full Text] [PDF]

				D. W. Voskuil, A. Vrieling, L. J. van't Veer, E. Kampman, and M. A. Rookus The Insulin-like Growth Factor System in Cancer Prevention: Potential of Dietary Intervention Strategies Cancer Epidemiol. Biomarkers Prev., January 1, 2005; 14(1): 195 - 203. [Abstract] [Full Text] [PDF]

				L. A. Colangelo, K. Liu, and S. M. Gapstur Insulin-like Growth Factor-1, Insulin-like Growth Factor Binding Protein-3, and Cardiovascular Disease Risk Factors in Young Black Men and White Men: The CARDIA Male Hormone Study Am. J. Epidemiol., October 15, 2004; 160(8): 750 - 757. [Abstract] [Full Text] [PDF]

				K. DeLellis, S. Rinaldi, R. J. Kaaks, L. N. Kolonel, B. Henderson, and L. Le Marchand Dietary and Lifestyle Correlates of Plasma Insulin-Like Growth Factor-I (IGF-I) and IGF Binding Protein-3 (IGFBP-3): The Multiethnic Cohort Cancer Epidemiol. Biomarkers Prev., September 1, 2004; 13(9): 1444 - 1451. [Abstract] [Full Text] [PDF]

				P. Stattin, S. Rinaldi, C. Biessy, U.-H. Stenman, G. Hallmans, and R. Kaaks High Levels of Circulating Insulin-Like Growth Factor-I Increase Prostate Cancer Risk: A Prospective Study in a Population-Based Nonscreened Cohort J. Clin. Oncol., August 1, 2004; 22(15): 3104 - 3112. [Abstract] [Full Text] [PDF]

				M. L. Slattery, W. Samowitz, K. Curtin, K. N. Ma, M. Hoffman, B. Caan, and S. Neuhausen Associations among IRS1, IRS2, IGF1, and IGFBP3 Genetic Polymorphisms and Colorectal Cancer Cancer Epidemiol. Biomarkers Prev., July 1, 2004; 13(7): 1206 - 1214. [Abstract] [Full Text] [PDF]