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The N314D Polymorphism of Galactose-1-Phosphate Uridyl Transferase Does Not Modify the Risk of Ovarian Cancer

The Center for Research in Women’s Health, University of Toronto, Toronto, Ontario, M5G 1N8 Canada [W. L. A. F., D. V., S. A. N.]; Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06510-8034 [H. R.]; The Samuel Lunenfeld Research Institute, M5G1X5 Toronto, Ontario, Canada [J. M.]; Department of Gynecology, Toronto Hospital, M5G2M9 Toronto, Ontario, Canada [B. R.]; and Department of Clinical Biochemistry, University of Toronto, M5G1L5 Toronto, Ontario, Canada [D. C.]

It has been proposed that high levels of galactose consumption increase the risk of ovarian cancer. Galactose levels are determined, in part, by the galactose-1-phosphate uridyl transferase gene (GALT). The N314D allele of the GALT gene has been associated with low GALT activity and with an increased risk of ovarian cancer. We screened for the presence of the N314D GALT allele in 891 incident cases of epithelial ovarian cancer and in 364 unaffected female controls. No significant difference in the prevalence of the N314D allele was observed between the cases (18.1%) and the controls (18.7%). The odds ratio associated with the presence of one N314D allele was 0.94 (95% confidence interval (CI), 0.68–1.3; P = 0.70), and the odds ratio associated with two N314D alleles was 1.62 (95% CI, 0.34–7.7; P = 0.54). Subanalyses of the cases by histological type, by age, by ethnic group, by family history, and by BRCA1/2 mutation status did not reveal any significant associations. We conclude that the GALT N314D allele does not predispose to epithelial ovarian cancer.

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