This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ntais, C. Articles by Ioannidis, J. P. A. Search for Related Content PubMed PubMed Citation Articles by Ntais, C. Articles by Ioannidis, J. P. A.

SRD5A2 Gene Polymorphisms and the Risk of Prostate Cancer

A Meta-Analysis

Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece [C. N., A. P., J. P. A. I.]; Biomedical Research Institute, Foundation for Research and Technology–Hellas, Ioannina 45110, Greece [J. P. A. I.]; and Division of Clinical Care Research, Department of Medicine, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111 [J. P. A. I.]

Several polymorphisms in the 5-reductase type 2 (SRD5A2) gene have been implicated as risk factors for prostate cancer. We performed a meta-analysis of 9 studies (12 comparisons) with V89L genotyping (2558 prostate cancer cases and 3349 controls), 7 studies (8 comparisons) with A49T genotyping (1594 cases and 2137 controls), and 4 studies with TA repeat genotyping (1109 cases and 1378 controls). The random effects odds ratio (OR) for the L versus V allele was 1.02 [95% confidence interval (CI), 0.94–1.11]. There was no suggestion of an overall effect either in recessive or dominant modeling, and comparison of L/L versus V/V also showed no differential prostate cancer susceptibility (OR, 1.03; 95% CI, 0.83–1.28). The random effects OR for the T versus A allele was 1.56 (95% CI, 0.93–2.62). However, excluding the first published study there was no evidence for any effect (OR, 1.08; 95% CI, 0.72–1.61). Moreover, the T allele had a low prevalence (0%, 1%, and 2% in Asian, African and European controls, respectively). The random effects OR for longer versus short TA alleles was 0.88 (95% CI, 0.74–1.05). Longer TA allele homozygotes were nonsignificantly under-represented among prostate cancer cases (OR, 0.53; 95% CI, 0.26–1.06). We exclude a role for the V89L polymorphism in conferring susceptibility to prostate cancer. The A49T and TA repeat polymorphisms may have a modest effect on prostate cancer susceptibility, but bias and chance findings cannot be excluded; any genuine genetic effects would account only for a small proportion of prostate cancer in the population.

This article has been cited by other articles:

				K. C. Torkko, A. van Bokhoven, P. Mai, J. Beuten, I. Balic, T. E. Byers, J. E. Hokanson, J. M. Norris, A. E. Baron, M. S. Lucia, et al. VDR and SRD5A2 Polymorphisms Combine to Increase Risk for Prostate Cancer in Both Non-Hispanic White and Hispanic White Men Clin. Cancer Res., May 15, 2008; 14(10): 3223 - 3229. [Abstract] [Full Text] [PDF]

				J. Beesley, S. J. Jordan, A. B. Spurdle, H. Song, S. J. Ramus, S. K. Kjaer, E. Hogdall, R. A. DiCioccio, V. McGuire, A. S. Whittemore, et al. Association Between Single-Nucleotide Polymorphisms in Hormone Metabolism and DNA Repair Genes and Epithelial Ovarian Cancer: Results from Two Australian Studies and an Additional Validation Set Cancer Epidemiol. Biomarkers Prev., December 1, 2007; 16(12): 2557 - 2565. [Abstract] [Full Text] [PDF]

				T. A. Trikalinos, G. Salanti, M. J. Khoury, and J. P. A. Ioannidis Impact of Violations and Deviations in Hardy-Weinberg Equilibrium on Postulated Gene-Disease Associations Am. J. Epidemiol., February 15, 2006; 163(4): 300 - 309. [Abstract] [Full Text] [PDF]

				H. T. T. Thai, M. Kalbasi, K. Lagerstedt, L. Frisen, I. Kockum, and A. Nordenskjold The Valine Allele of the V89L Polymorphism in the 5-{alpha}-Reductase Gene Confers a Reduced Risk for Hypospadias J. Clin. Endocrinol. Metab., December 1, 2005; 90(12): 6695 - 6698. [Abstract] [Full Text] [PDF]

				C. Ntais, A. Polycarpou, and J. P.A. Ioannidis Association of GSTM1, GSTT1, and GSTP1 Gene Polymorphisms with the Risk of Prostate Cancer: A Meta-analysis Cancer Epidemiol. Biomarkers Prev., January 1, 2005; 14(1): 176 - 181. [Abstract] [Full Text] [PDF]

				D. J. Schaid The complex genetic epidemiology of prostate cancer Hum. Mol. Genet., April 1, 2004; 13(90001): R103 - 121. [Abstract] [Full Text] [PDF]

				C. Ntais, A. Polycarpou, and J. P. A. Ioannidis Vitamin D Receptor Gene Polymorphisms and Risk of Prostate Cancer: A Meta-analysis Cancer Epidemiol. Biomarkers Prev., December 1, 2003; 12(12): 1395 - 1402. [Abstract] [Full Text] [PDF]