This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Corpet, D. E. Articles by Pierre, F. Search for Related Content PubMed PubMed Citation Articles by Corpet, D. E. Articles by Pierre, F.

Point: From Animal Models to Prevention of Colon Cancer. Systematic Review of Chemoprevention in Min Mice and Choice of the Model System

UMR Xenobiotiques, Institut National Recherche Agronomique, Ecole Nationale Veterinaire Toulouse, 31076 Toulouse, France

The Apc^Min/+ mouse model and the azoxymethane (AOM) rat model are the main animal models used to study the effect of dietary agents on colorectal cancer. We reviewed recently the potency of chemopreventive agents in the AOM rat model (D. E. Corpet and S. Tache, Nutr. Cancer, 43: 1–21, 2002). Here we add the results of a systematic review of the effect of dietary and chemopreventive agents on the tumor yield in Min mice. The review is based on the results of 179 studies from 71 articles and is displayed also on the internet http://corpet.net/min.² We compared the efficacy of agents in the Min mouse model and the AOM rat model, and found that they were correlated (r = 0.66; P < 0.001), although some agents that afford strong protection in the AOM rat and the Min mouse small bowel increase the tumor yield in the large bowel of mutant mice. The agents included piroxicam, sulindac, celecoxib, difluoromethylornithine, and polyethylene glycol. The reason for this discrepancy is not known. We also compare the results of rodent studies with those of clinical intervention studies of polyp recurrence. We found that the effect of most of the agents tested was consistent across the animal and clinical models. Our point is thus: rodent models can provide guidance in the selection of prevention approaches to human colon cancer, in particular they suggest that polyethylene glycol, hesperidin, protease inhibitor, sphingomyelin, physical exercise, epidermal growth factor receptor kinase inhibitor, (+)-catechin, resveratrol, fish oil, curcumin, caffeate, and thiosulfonate are likely important preventive agents.

This article has been cited by other articles:

				F. Di Cello, J. Hillion, J. Kowalski, B. M. Ronnett, A. Aderinto, D. L. Huso, and L. M.S. Resar Cyclooxygenase inhibitors block uterine tumorigenesis in HMGA1a transgenic mice and human xenografts Mol. Cancer Ther., July 1, 2008; 7(7): 2090 - 2095. [Abstract] [Full Text] [PDF]

				M. J. Sinnamon, K. J. Carter, L. P. Sims, B. LaFleur, B. Fingleton, and L. M. Matrisian A protective role of mast cells in intestinal tumorigenesis Carcinogenesis, April 1, 2008; 29(4): 880 - 886. [Abstract] [Full Text] [PDF]

				N. Korsisaari, I. M. Kasman, W. F. Forrest, N. Pal, W. Bai, G. Fuh, F. V. Peale, R. Smits, and N. Ferrara From the Cover: Inhibition of VEGF-A prevents the angiogenic switch and results in increased survival of Apc+/min mice PNAS, June 19, 2007; 104(25): 10625 - 10630. [Abstract] [Full Text] [PDF]

				J. M. Amos-Landgraf, L. N. Kwong, C. M. Kendziorski, M. Reichelderfer, J. Torrealba, J. Weichert, J. D. Haag, K.-S. Chen, J. L. Waller, M. N. Gould, et al. A target-selected Apc-mutant rat kindred enhances the modeling of familial human colon cancer PNAS, March 6, 2007; 104(10): 4036 - 4041. [Abstract] [Full Text] [PDF]

				M. V. Cespedes, C. Espina, M. A. Garcia-Cabezas, M. Trias, A. Boluda, M. T. Gomez del Pulgar, F. J. Sancho, M. Nistal, J. C. Lacal, and R. Mangues Orthotopic Microinjection of Human Colon Cancer Cells in Nude Mice Induces Tumor Foci in All Clinically Relevant Metastatic Sites Am. J. Pathol., March 1, 2007; 170(3): 1077 - 1085. [Abstract] [Full Text] [PDF]

				V. P. Rao, T. Poutahidis, J. G. Fox, and S. E. Erdman Breast Cancer: Should Gastrointestinal Bacteria Be on Our Radar Screen? Cancer Res., February 1, 2007; 67(3): 847 - 850. [Abstract] [Full Text] [PDF]

				R. D. Cardiff, M. R. Anver, G. P. Boivin, M. W. Bosenberg, R. R. Maronpot, A. A. Molinolo, A. Y. Nikitin, J. E. Rehg, G. V. Thomas, R. G. Russell, et al. Precancer in Mice: Animal Models Used to Understand, Prevent, and Treat Human Precancers Toxicol Pathol, October 1, 2006; 34(6): 699 - 707. [Abstract] [Full Text] [PDF]

				L. H. Colbert, V. Mai, J. A. Tooze, S. N. Perkins, D. Berrigan, and S. D. Hursting Negative energy balance induced by voluntary wheel running inhibits polyp development in APCMin mice Carcinogenesis, October 1, 2006; 27(10): 2103 - 2107. [Abstract] [Full Text] [PDF]

				R.A. Goodlad, A.J. Ryan, S.R. Wedge, I.T. Pyrah, D. Alferez, R. Poulsom, N.R. Smith, N. Mandir, A.J. Watkins, and R.W. Wilkinson Inhibiting vascular endothelial growth factor receptor-2 signaling reduces tumor burden in the ApcMin/+ mouse model of early intestinal cancer Carcinogenesis, October 1, 2006; 27(10): 2133 - 2139. [Abstract] [Full Text] [PDF]

				J. S. Munday, M. M. Brennan, and M. Kiupel Altered Expression of {beta}-catenin, E-cadherin, Cycloxygenase-2, and p53 Protein by Ovine Intestinal Adenocarcinoma Cells. Vet. Pathol., September 1, 2006; 43(5): 613 - 621. [Abstract] [Full Text] [PDF]

				J. I. Fenton and N. G. Hord Stage matters: choosing relevant model systems to address hypotheses in diet and cancer chemoprevention research Carcinogenesis, May 1, 2006; 27(5): 893 - 902. [Abstract] [Full Text] [PDF]

				R. Irons, B. A. Carlson, D. L. Hatfield, and C. D. Davis Both Selenoproteins and Low Molecular Weight Selenocompounds Reduce Colon Cancer Risk in Mice with Genetically Impaired Selenoprotein Expression J. Nutr., May 1, 2006; 136(5): 1311 - 1317. [Abstract] [Full Text] [PDF]

				K. A. Mehl, J. M. Davis, F. G. Berger, and J. A. Carson Myofiber degeneration/regeneration is induced in the cachectic ApcMin/+ mouse J Appl Physiol, December 1, 2005; 99(6): 2379 - 2387. [Abstract] [Full Text] [PDF]

				J. Ju, J. Hong, J.-n. Zhou, Z. Pan, M. Bose, J. Liao, G.-y. Yang, Y. Y. Liu, Z. Hou, Y. Lin, et al. Inhibition of Intestinal Tumorigenesis in Apcmin/+ Mice by (-)-Epigallocatechin-3-Gallate, the Major Catechin in Green Tea Cancer Res., November 15, 2005; 65(22): 10623 - 10631. [Abstract] [Full Text] [PDF]

				S.W. Barth, C. Fahndrich, A. Bub, H. Dietrich, B. Watzl, F. Will, K. Briviba, and G. Rechkemmer Cloudy apple juice decreases DNA damage, hyperproliferation and aberrant crypt foci development in the distal colon of DMH-initiated rats Carcinogenesis, August 1, 2005; 26(8): 1414 - 1421. [Abstract] [Full Text] [PDF]

				K. A. Mehl, J. M. Davis, J. M. Clements, F. G. Berger, M. M. Pena, and J. A. Carson Decreased intestinal polyp multiplicity is related to exercise mode and gender in ApcMin/+ mice J Appl Physiol, June 1, 2005; 98(6): 2219 - 2225. [Abstract] [Full Text] [PDF]

				S. E. Erdman, J. J. Sohn, V. P. Rao, P. R. Nambiar, Z. Ge, J. G. Fox, and D. B. Schauer CD4+CD25+ Regulatory Lymphocytes Induce Regression of Intestinal Tumors in ApcMin/+ Mice Cancer Res., May 15, 2005; 65(10): 3998 - 4004. [Abstract] [Full Text] [PDF]

				F. G. Bottone Jr., Y. Moon, J. S. Kim, B. Alston-Mills, M. Ishibashi, and T. E. Eling The anti-invasive activity of cyclooxygenase inhibitors is regulated by the transcription factor ATF3 (activating transcription factor 3) Mol. Cancer Ther., May 1, 2005; 4(5): 693 - 703. [Abstract] [Full Text] [PDF]

				C. Ngyuen, H. Ma, M. Eguchi, and M. Kahn ICG-001, a Novel Chemogenomic Tool to Investigate the Wnt Pathway in Cancer Am. Assoc. Cancer Res. Educ. Book, April 1, 2005; 2005(1): 45 - 50. [Full Text] [PDF]

				E. T. Hawk and B. Levin Colorectal Cancer Prevention J. Clin. Oncol., January 10, 2005; 23(2): 378 - 391. [Abstract] [Full Text] [PDF]

				K. H. Emami, C. Nguyen, H. Ma, D. H. Kim, K. W. Jeong, M. Eguchi, R. T. Moon, J.-L. Teo, S. W. Oh, H. Y. Kim, et al. A small molecule inhibitor of {beta}-catenin/CREB-binding protein transcription PNAS, August 24, 2004; 101(34): 12682 - 12687. [Abstract] [Full Text] [PDF]

				F. G. Bottone Jr, J. M. Martinez, B. Alston-Mills, and T. E. Eling Gene modulation by Cox-1 and Cox-2 specific inhibitors in human colorectal carcinoma cancer cells Carcinogenesis, March 1, 2004; 25(3): 349 - 357. [Abstract] [Full Text] [PDF]

				A. J. Gescher and W. P. Steward Relationship between Mechanisms, Bioavailibility, and Preclinical Chemopreventive Efficacy of Resveratrol: A Conundrum Cancer Epidemiol. Biomarkers Prev., October 1, 2003; 12(10): 953 - 957. [Full Text] [PDF]

				W. R. Bruce Counterpoint: From Animal Models to Prevention of Colon Cancer. Criteria for Proceeding from Preclinical Studies and Choice of Models for Prevention Studies Cancer Epidemiol. Biomarkers Prev., May 1, 2003; 12(5): 401 - 404. [Abstract] [Full Text] [PDF]