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Cancer Epidemiology Biomarkers & Prevention Vol. 12, 1112-1115, October 2003
© 2003 American Association for Cancer Research

Short Communications

Evidence for a Familial Esophageal Cancer Susceptibility Gene on Chromosome 13

Nan Hu, Alisa M. Goldstein, Paul S. Albert, Carol Giffen, Ze-Zhong Tang, Ti Ding, Philip R. Taylor1 and Michael R. Emmert-Buck2

Center for Cancer Research [N. H., P. R. T., M. R. E-B.], Division of Cancer Epidemiology and Genetics [A. M. G.], and Division of Cancer Treatment and Diagnosis [P. S. A.], National Cancer Institute, Bethesda, Maryland 20892; Information Management Services, Inc., Silver Spring, Maryland 20904 [C. G.]; and Shanxi Cancer Hospital, Taiyuan, Shanxi 030013, People’s Republic of China [Z-Z. T., T. D.]

Previous segregation analyses of pedigrees from areas of China where esophageal squamous cell carcinoma (ESCC) rates are extraordinarily high suggested a Mendelian mode of transmission. We initiated a search for a major ESCC gene by conducting a genome-wide scan in ESCC tumors. Chromosome 13 showed loss of heterozygosity (LOH) in 95% of microsatellite markers, the highest frequency of LOH on any chromosome. In the current study, we established a high-resolution deletion map using 107 markers on 13q and compared LOH frequency by family history of upper gastrointestinal cancer. Overall allelic loss was significantly higher in those with a positive (versus negative) family history, suggesting the presence of an inherited tumor suppressor gene on 13q in ESCC.




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 Mol Cancer ResHome page
J. M.Y. Ko, P. L. Chan, W. L. Yau, H. K. Chan, K. C. Chan, Z. Y. Yu, F. M. Kwong, L. D. Miller, E. T. Liu, L. C. Yang, et al.
Monochromosome Transfer and Microarray Analysis Identify a Critical Tumor-Suppressive Region Mapping to Chromosome 13q14 and THSD1 in Esophageal Carcinoma
Mol. Cancer Res., April 1, 2008; 6(4): 592 - 603.
[Abstract] [Full Text] [PDF]


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Copyright © 2003 by the American Association for Cancer Research.