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Cancer Epidemiology Biomarkers & Prevention Vol. 12, 1112-1115, October 2003
© 2003 American Association for Cancer Research

Short Communications

Evidence for a Familial Esophageal Cancer Susceptibility Gene on Chromosome 13

Nan Hu, Alisa M. Goldstein, Paul S. Albert, Carol Giffen, Ze-Zhong Tang, Ti Ding, Philip R. Taylor1 and Michael R. Emmert-Buck2

Center for Cancer Research [N. H., P. R. T., M. R. E-B.], Division of Cancer Epidemiology and Genetics [A. M. G.], and Division of Cancer Treatment and Diagnosis [P. S. A.], National Cancer Institute, Bethesda, Maryland 20892; Information Management Services, Inc., Silver Spring, Maryland 20904 [C. G.]; and Shanxi Cancer Hospital, Taiyuan, Shanxi 030013, People’s Republic of China [Z-Z. T., T. D.]

Previous segregation analyses of pedigrees from areas of China where esophageal squamous cell carcinoma (ESCC) rates are extraordinarily high suggested a Mendelian mode of transmission. We initiated a search for a major ESCC gene by conducting a genome-wide scan in ESCC tumors. Chromosome 13 showed loss of heterozygosity (LOH) in 95% of microsatellite markers, the highest frequency of LOH on any chromosome. In the current study, we established a high-resolution deletion map using 107 markers on 13q and compared LOH frequency by family history of upper gastrointestinal cancer. Overall allelic loss was significantly higher in those with a positive (versus negative) family history, suggesting the presence of an inherited tumor suppressor gene on 13q in ESCC.




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J. M.Y. Ko, P. L. Chan, W. L. Yau, H. K. Chan, K. C. Chan, Z. Y. Yu, F. M. Kwong, L. D. Miller, E. T. Liu, L. C. Yang, et al.
Monochromosome Transfer and Microarray Analysis Identify a Critical Tumor-Suppressive Region Mapping to Chromosome 13q14 and THSD1 in Esophageal Carcinoma
Mol. Cancer Res., April 1, 2008; 6(4): 592 - 603.
[Abstract] [Full Text] [PDF]


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Copyright © 2003 by the American Association for Cancer Research.