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Family History of Autoimmune Thyroid Disease and Childhood Acute Leukemia¹

Institut National de la Santé et de la Recherche Médicale, INSERM U170, 94807 Villejuif, France [F. P., J. C., D. H.]; Institut National de la Santé et de la Recherche Médicale, Institute of Hematology, Saint-Louis Hospital, 75010 Paris, France [M-F. A.]; Department of Pediatric Hematology, Saint-Louis Hospital, Paris, France [A. B.]; Department of Pediatric Hematology, Armand Trousseau Hospital, Paris, France [G. L.]; Department of Pediatric Hematology-Oncology, Jeanne de Flandre Hospital, Lille, France [B. N.]; Department of Pediatric Hematology, Debrousse Hospital, Lyon, France [N. P.]; Department of Pediatric Hematology, Brabois Hospital, Nancy, France [D. S.]; and Department of Pediatric Hematology-Immunology, Robert Debré Hospital, Paris, France [E. V.]

The association between a familial history of autoimmune disease and childhood acute leukemia was investigated in a French case-control study that, overall, was designed to assess the role of perinatal, infectious, environmental, and genetic factors in the etiology of childhood acute leukemia. Familial histories of autoimmune disease in first- and second-degree relatives were compared in 279 incident cases, 240 cases of acute lymphocytic leukemia (ALL) and 39 cases of acute non-lymphoblastic leukemia (ANLL), and 285 controls. Recruitment was frequency matched by age, gender, hospital, and ethnic origin. Odds ratios (OR) were estimated using an unconditional regression model taking into account the stratification variables, socioeconomic status, and familial structure. A statistically significant association between a history of autoimmune disease in first- or second-degree relatives and ALL (OR, 1.7; 95% confidence interval (CI), 1.0–2.8) was found. A relationship between thyroid diseases overall and ALL (OR, 2.0; 95% CI, 1.0–3.9) was observed. This association was more pronounced for potentially autoimmune thyroid diseases (Grave’s disease and/or hyperthyroidism and Hashimoto’s disease and/or hypothyroidism) (OR, 3.5; 95% CI, 1.1–10.7 and OR, 5.6; 95% CI, 1.0–31.1, respectively for ALL and ANLL), whereas it was not statistically significant for the other thyroid diseases (thyroid goiter, thyroid nodule, and unspecified thyroid disorders) (OR, 1.6; 95% CI, 0.7–3.5 and OR, 1.3; 95% CI, 0.2–7.0, respectively, for ALL and ANLL). The results suggest that a familial history of autoimmune thyroid disease may be associated with childhood acute leukemia.

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