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Risk of Cancer among Relatives of Patients with Glioma¹

Departments of Neurology [B. P. O., D. W. K., W. A. R.], Health Sciences Research [P. Y., W. A. R.], and Laboratory Medicine, Mayo Clinic and Foundation [R. B. J., B. W. S.], and the Mayo Clinic Cancer Center, Rochester Minnesota 55905 [B. P. O., P. Y., R. B. J., D. W. K., B. W. S.]; Department of Anatomy and Pathology, University of Iceland, Reykjavik, Iceland [H. B., J. B.]; and the Icelandic Cancer Registry, Reykjavik, Iceland [G. H. O., H. S., H. T.]

We report a population-based, retrospective study of 396 Icelandic people diagnosed with glioma in the years 1940–1995. The purpose of this study was to test whether astrocytomas, other glial tumors, other central nervous system tumors, or other cancers aggregate in families identified through glioma probands who were of Icelandic origin. Pedigrees of the 396 cases were traced by the Genetical Committee of the University of Iceland and linked to the Icelandic Cancer Registry. A total of 25,546 relatives, including 2,080 individuals with cancer were identified within these pedigrees. There was no statistically significant increase of glioma in relatives of glioma patients, nor was there any statistically significant increase in risk for other central nervous system tumors. There was no overall increase in incidence of all cancer combined, nor of specific common cancers (lung, prostate, breast, stomach, and colorectal) and uncommon cancers (melanoma and pancreas) in the relatives of glioma patients. Our results do not support the hypothesis of a familial aggregation of glioma indicative of a glioma susceptibility gene.

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