This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sedjo, R. L. Articles by Giuliano, A. R. Search for Related Content PubMed PubMed Citation Articles by Sedjo, R. L. Articles by Giuliano, A. R.

Vitamin A, Carotenoids, and Risk of Persistent Oncogenic Human Papillomavirus Infection¹

Arizona Cancer Center [R. L. S., D. J. R., M. A., R. B. H., S. B., A. R. G.], Arizona College of Public Health [D. J. R., R. B. H., A. R. G.], and Obstetrics and Gynecology [S. B.], University of Arizona, Tucson, Arizona 85724, and Craft Technologies, Inc., Wilson, North Carolina 27893 [N. C.]

Oncogenic human papillomavirus (HPV) infection is the main etiologic factor for cervical neoplasia, although infection alone is insufficient to produce disease. Cofactors such as nutritional factors may be necessary for viral progression to neoplasia. Results from previous studies have suggested that higher dietary consumption and circulating levels of certain micronutrients may be protective against cervical neoplasia. This study evaluated the role of vitamin A and carotenoids on HPV persistence comparing women with intermittent and persistent infections. As determined by the Hybrid Capture II system, oncogenic HPV infections were assessed at baseline and at approximately 3 and 9 months postbaseline. Multivariate logistic regression analysis was used to determine the risk of persistent HPV infection associated with each tertile of dietary and circulating micronutrients. Higher levels of vegetable consumption were associated with a 54% decrease risk of HPV persistence (adjusted odds ratio, 0.46; 95% confidence interval, 0.21–0.97). Also, a 56% reduction in HPV persistence risk was observed in women with the highest plasma cis-lycopene concentrations compared with women with the lowest plasma cis-lycopene concentrations (adjusted odds ratio, 0.44; 95% confidence interval, 0.19–1.01). These data suggest that vegetable consumption and circulating cis-lycopene may be protective against HPV persistence.

This article has been cited by other articles:

				C. J. Kavanaugh, P. R. Trumbo, and K. C. Ellwood The U.S. Food and Drug Administration's Evidence-Based Review for Qualified Health Claims: Tomatoes, Lycopene, and Cancer J Natl Cancer Inst, July 18, 2007; 99(14): 1074 - 1085. [Abstract] [Full Text] [PDF]

				M. T. Goodman, Y. B. Shvetsov, K. McDuffie, L. R. Wilkens, X. Zhu, A. A. Franke, C. C. Bertram, B. Kessel, M. Bernice, C. Sunoo, et al. Hawaii Cohort Study of Serum Micronutrient Concentrations and Clearance of Incident Oncogenic Human Papillomavirus Infection of the Cervix Cancer Res., June 15, 2007; 67(12): 5987 - 5996. [Abstract] [Full Text] [PDF]

				H. Richardson, M. Abrahamowicz, P.-P. Tellier, G. Kelsall, R. du Berger, A. Ferenczy, F. Coutlee, and E. L. Franco Modifiable Risk Factors Associated with Clearance of Type-Specific Cervical Human Papillomavirus Infections in a Cohort of University Students Cancer Epidemiol. Biomarkers Prev., May 1, 2005; 14(5): 1149 - 1156. [Abstract] [Full Text] [PDF]

				H.-U. Bernard Established and potential strategies against papillomavirus infections J. Antimicrob. Chemother., February 1, 2004; 53(2): 137 - 139. [Abstract] [Full Text] [PDF]

				P. E. Castle and A. R. Giuliano Chapter 4: Genital Tract Infections, Cervical Inflammation, and Antioxidant Nutrients--Assessing Their Roles as Human Papillomavirus Cofactors J Natl Cancer Inst Monographs, June 1, 2003; 2003(31): 29 - 34. [Abstract] [Full Text] [PDF]