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Environmental Toxins and Breast Cancer on Long Island. II. Organochlorine Compound Levels in Blood¹

Department of Epidemiology, University of North Carolina, School of Public Health, Chapel Hill, North Carolina 27599 [M. D. G.]; Mt. Sinai School of Medicine, Department of Community and Preventive Medicine, New York, New York 10029 [M. S. W., S. L. T., J. A. B., M. H., G. B., N. N., K. I.]; Departments of Medicine [A. I. N.] and Surgery [F. S.], Columbia University, College of Physicians and Surgeons, New York, New York 10032; Divisions of Epidemiology [A. I. N., S. M. E., M. B. T., S. D. S., R. S., G. G.], Biostatistics [B. L.], Sociomedical Sciences [R. S.], and Environmental Health Sciences [G. G., N. N., R. M. S.], Columbia University, Mailman School of Public Health, New York, New York 10032; American Health Foundation, Valhalla, New York 10595 [S. D. S.]; Departments of Preventive Medicine [G. C. K.] and Surgery [M. K.], State University of New York, Stony Brook, New York 11794; Strang Research Laboratory, Cornell Medical Center, New York, New York 10020 [H. L. B.]; Westat, Inc., Rockville, Maryland 20850 [C. M., P. M.]; ProHealth Care Associates, LLP, Lake Success, New York 11042 [M. C.]; Department of Pathology, Winthrop University Hospital, Mineola, New York 11042 [A. S.]; and Departments of Pathology [S. H.] and Medicine [V. V.], North Shore University Hospital, Manhasset, New York 11030

Whether environmental contaminants increase breast cancerrisk among women on Long Island, NY, is unknown. The study objective is to determine whether breast cancer risk is increased in relation to organochlorines, compounds with known estrogenic characteristics that were extensively used on Long Island and other areas of the United States. Recent reports do not support a strong association, although there are concerns with high risks observed in subgroups of women. Blood samples from 646 case and 429 control women from a population-based case-control study conducted on Long Island were analyzed. No substantial elevation in breast cancer risk was observed in relation to the highest quintile of lipid-adjusted serum levels of p,p'-bis(4-chlorophenyl)-1,1-dichloroethene (DDE) [odds ratio (OR), 1.20 versus lowest quintile; 95% confidence interval (CI), 0.76–1.90], chlordane (OR, 0.98; 95% CI, 0.62–1.55), dieldrin (OR, 1.37; 95% CI, 0.69–2.72), the sum of the four most frequently occurring PCB congeners (nos. 118, 153, 138, and 180; OR, 0.83; 95% CI, 0.54–1.29), and other PCB congener groupings. No dose-response relations were apparent. Nor was risk increased in relation to organochlorines among women who had not breastfed or were overweight, postmenopausal, or long-term residents of Long Island; or with whether the case was diagnosed with invasive rather than in situ disease, or with a hormone receptor-positive tumor. These findings, based on the largest number of samples analyzed to date among primarily white women, do not support the hypothesis that organochlorines increase breast cancer risk among Long Island women.

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