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Mammographic Parenchymal Patterns and Self-reported Soy Intake in Singapore Chinese Women¹

National Medical Research Council Clinical Trials and Epidemiology Research Unit, Singapore 169039 [R. W. J.]; Cancer Research UK, London, WC2A 3PX [S. W. D.]; Department of Radiology, Singapore General Hospital, Singapore 169608 [F-C. N.]; Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore 169610 [F. G.]; Mount Elisabeth Medical Centre, Singapore 228510 [E-H. N.]; Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore 117597 [A. S., H-P. L.]; and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90033 [M. C. Y.]

The study aimed to investigate whether self-reported dietaryvariables were associated with mammographic parenchymal patterns, which have been shown to predict risk of breast cancer. Among the 3,421 women, ages 45–74 years, common to two independent population-based cohorts, mammographic parenchymal patterns and current dietary habits were assessed for 406 randomly chosen participants. Logistic regression methods were used to compare dietary and other lifestyle profiles between subjects classified as displaying high (cases) and low risk (controls) parenchymal patterns. After adjustment for energy intake and other potential confounders, dietary soy protein intake was inversely related to risk of high-risk parenchymal pattern (odds ratio, 0.41; 95% confidence interval, 0.18–0.94, highest versus lowest quartile of intake). Similarly, the highest versus lowest quartile of dietary soy isoflavone intake was significantly related to low-risk parenchymal patterns (odds ratio, 0.44; 95% confidence interval, 0.20–0.98). The association between high soy intake and a reduced risk of mammographic parenchymal patterns that are associated with high breast cancer risk may have important implications in breast cancer prevention.

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