This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Schoen, R. E. Articles by Kuller, L. H. Search for Related Content PubMed PubMed Citation Articles by Schoen, R. E. Articles by Kuller, L. H.

Lack of Association between Adipose Tissue Distribution and IGF-1 and IGFBP-3 in Men and Women¹

Departments of Epidemiology [R. E. S., J. S., J. L. W., R. W. E., L. H. K.], Medicine [R. E. S.], and Radiology [F. L. T.], University of Pittsburgh, Pittsburgh, Pennsylvania 15213-2582, and The Jackson Laboratory, Bar Harbor, Maine 04609 [C. J. R.]

Insulin, insulin-like growth factor-1 (IGF-1), IGF binding protein-3 (IGFBP-3), and obesity, and in particular visceral obesity, are putative cancer risk factors. Little is known, however, about the relationship between IGFs and obesity. We investigated the relationship between adipose tissue distribution and IGF-1 and IGFBP-3. Single-slice abdominal computed tomography scanning through the L4-L5 interspace was used to measure visceral adipose tissue (VAT) and subcutaneous adipose tissue (SQAT) in 432 community-based subjects (267 men, 165 women; ages, 55–77), participating in a cancer screening trial. Insulin, IGF-1, IGFBP-3, and the ratio of IGF-1:IGFBP-3, measured by radioimmunoassay, were compared with age, body mass index, absolute and relative VAT and SQAT, and total abdominal fat. We found that men had a higher mean IGF-1 (129.5 versus 108.9 ng/ml; P < 0.0001) and more VAT (201.5 cm³ versus 166.6 cm³; P < 0.0001) than women. In men and women, there was no correlation between IGF-1, IGFBP-3, or the ratio of IGF-1:IGFBP-3 with body mass index, total fat, VAT or SQAT, or fasting insulin. In contrast, fasting insulin was highly correlated to all measures of obesity (P = 0.0001). We conclude that obesity, adipose tissue distribution, and in particular VAT are not correlated with IGF-1, IGFBP-3, or the molar ratio of IGF-1:IGFBP-3. The lack of association between obesity and the IGF-1 axis suggests that the IGF-1 axis is not a likely mediator between VAT and disease.

This article has been cited by other articles:

				D. A Corley Obesity and the rising incidence of oesophageal and gastric adenocarcinoma: what is the link? Gut, November 1, 2007; 56(11): 1493 - 1494. [Full Text] [PDF]

				R. L. Ahmed, W. Thomas, and K. H. Schmitz Interactions between Insulin, Body Fat, and Insulin-Like Growth Factor Axis Proteins Cancer Epidemiol. Biomarkers Prev., March 1, 2007; 16(3): 593 - 597. [Abstract] [Full Text] [PDF]

				K. D. Henderson, M. I. Goran, L. N. Kolonel, B. E. Henderson, and L. Le Marchand Ethnic Disparity in the Relationship between Obesity and Plasma Insulin-Like Growth Factors: The Multiethnic Cohort. Cancer Epidemiol. Biomarkers Prev., November 1, 2006; 15(11): 2298 - 2302. [Abstract] [Full Text] [PDF]

				G. Onder, R. Liperoti, A. Russo, M. Soldato, E. Capoluongo, S. Volpato, M. Cesari, F. Ameglio, R. Bernabei, and F. Landi Body mass index, free insulin-like growth factor I, and physical function among older adults: results from the ilSIRENTE study Am J Physiol Endocrinol Metab, October 1, 2006; 291(4): E829 - E834. [Abstract] [Full Text] [PDF]

				M. L. Irwin, A. McTiernan, L. Bernstein, F. D. Gilliland, R. Baumgartner, K. Baumgartner, and R. Ballard-Barbash Relationship of Obesity and Physical Activity with C-Peptide, Leptin, and Insulin-Like Growth Factors in Breast Cancer Survivors Cancer Epidemiol. Biomarkers Prev., December 1, 2005; 14(12): 2881 - 2888. [Abstract] [Full Text] [PDF]

				L. M. Morimoto, P. A. Newcomb, E. White, J. Bigler, and J. D. Potter Variation in Plasma Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3: Genetic Factors Cancer Epidemiol. Biomarkers Prev., June 1, 2005; 14(6): 1394 - 1401. [Abstract] [Full Text] [PDF]

				S. M. Gapstur, P. Kopp, B. C-H. Chiu, P. H. Gann, L. A. Colangelo, and K. Liu Longitudinal Associations of Age, Anthropometric and Lifestyle Factors with Serum Total Insulin-Like Growth Factor-I and IGF Binding Protein-3 Levels in Black and White Men: the CARDIA Male Hormone Study Cancer Epidemiol. Biomarkers Prev., December 1, 2004; 13(12): 2208 - 2216. [Abstract] [Full Text] [PDF]

				W. Shen, M. Punyanitya, Z. Wang, D. Gallagher, M.-P. St-Onge, J. Albu, S. B Heymsfield, and S. Heshka Visceral adipose tissue: relations between single-slice areas and total volume Am. J. Clinical Nutrition, August 1, 2004; 80(2): 271 - 278. [Abstract] [Full Text] [PDF]

				M. S. Sandhu, J. M. Gibson, A. H. Heald, D. B. Dunger, and N. J. Wareham Association between Insulin-Like Growth Factor-I: Insulin-Like Growth Factor-Binding Protein-1 Ratio and Metabolic and Anthropometric Factors in Men and Women Cancer Epidemiol. Biomarkers Prev., January 1, 2004; 13(1): 166 - 170. [Abstract] [Full Text] [PDF]

				N. M. Probst-Hensch, H. Wang, V. H. H. Goh, A. Seow, H.-P. Lee, and M. C. Yu Determinants of Circulating Insulin-like Growth Factor I and Insulin-like Growth Factor Binding Protein 3 Concentrations in a Cohort of Singapore Men and Women Cancer Epidemiol. Biomarkers Prev., August 1, 2003; 12(8): 739 - 746. [Abstract] [Full Text] [PDF]

				D. L. Waters, C. L. Yau, G. D. Montoya, and R. N. Baumgartner Serum Sex Hormones, IGF-1, and IGFBP3 Exert a Sexually Dimorphic Effect on Lean Body Mass in Aging J. Gerontol. A Biol. Sci. Med. Sci., July 1, 2003; 58(7): M648 - 652. [Abstract] [Full Text] [PDF]

				J. A. Britton, S. L. Teitelbaum, and M. S. Wolff Correspondence re: Schoen et al., Lack of Association between Adipose Tissue Distribution, and Insulin-like Growth Factor-I and Insulin-like Growth Factor Binding Protein-3 in Men and Women. Cancer Epidemiol. Biomark. Prev., 11: 581-586, 2002 Cancer Epidemiol. Biomarkers Prev., June 1, 2003; 12(6): 586 - 586. [Full Text] [PDF]