| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Duke Comprehensive Cancer Center [C. M. M., I. M. L., P. L.], Duke Department of Community and Family Medicine [C. M. M., B. K. R.], H. P. Lee Moffit Cancer Center and Research Institute [G. B.], Center for Clinical Health Policy Research, Duke University Medical Center [G. S., S. D.], Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill [J. A.], Chapel Hill, North Carolina, and Division of Cancer Control and Population Sciences, National Cancer Institute, NIH, Bethesda, Maryland 20892 [B. K. R.]
Purpose: Markers of genetic susceptibility to tobacco-related cancers couldpersonalize harms of smoking and motivate cessation. Our objective was to assess whether a multicomponent intervention that included feedback about genetic susceptibility to lung cancer increased risk perceptions and rates of smoking cessation compared with a standard cessation intervention.
Experimental Design: Our design was a two-arm trial with eligible smokers randomized in a 1:2 ratio to Enhanced Usual Care or Biomarker Feedback (BF). Surveys were conducted at baseline, 6, and 12 months later. The setting was an inner city community health clinic. African-American patients who were current smokers (n = 557) were identified by chart abstraction and provider referral. All smokers received a self-help manual and, if appropriate, nicotine patches. Smokers in the BF arm also were offered a blood test for genotyping the GST3 gene (GSTM1), sent a test result booklet, and called up to four times by a health educator. Prevalent abstinence was assessed by self-report of having smoked no cigarettes in the prior 7 days at the 6- and 12-month follow-ups and sustained abstinence, i.e., not smoking at either follow-up or in-between.
Results: Smoking cessation was greater for the BF arm than the Enhanced Usual Care arm (19% versus 10%, respectively; P < 0.006) at 6 months but not at 12 months.
Conclusions: Smokers agreed to genetic feedback as part of a multicomponent cessation program. Although the program increased short-term cessation rates compared with standard intervention, genetic feedback of susceptibility may not benefit smokers with high baseline risk perceptions.
This article has been cited by other articles:
|
|
 |
|
  S. C. Sanderson, S. E. Humphries, C. Hubbart, E. Hughes, M. J. Jarvis, and J. Wardle Psychological and Behavioural Impact of Genetic Testing Smokers for Lung Cancer Risk: A Phase II Exploratory Trial J Health Psychol, May 1, 2008; 13(4): 481 - 494. [Abstract] [PDF]
|
|
|
|
 |
|
 C. Carlsten, G. S. Sagoo, A. J. Frodsham, W. Burke, and J. P. T. Higgins Glutathione S-Transferase M1 (GSTM1) Polymorphisms and Lung Cancer: A Literature-based Systematic HuGE Review and Meta-Analysis Am. J. Epidemiol., April 1, 2008; 167(7): 759 - 774. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Davis, L. M. Vinci, T. M. Okwuosa, A. R. Chase, and E. S. Huang Cardiovascular Health Disparities: A Systematic Review of Health Care Interventions Med Care Res Rev, October 1, 2007; 64(5_suppl): 29S - 100S. [Abstract] [PDF]
|
|
|
|
 |
|
 C. M. McBride and L. C. Brody Point: Genetic Risk Feedback for Common Disease Time to Test the Waters Cancer Epidemiol. Biomarkers Prev., September 1, 2007; 16(9): 1724 - 1726. [Full Text] [PDF]
|
|
|
|
 |
|
 R. Bize, B. Burnand, Y. Mueller, and J. Cornuz Effectiveness of biomedical risk assessment as an aid for smoking cessation: a systematic review Tob. Control, June 1, 2007; 16(3): 151 - 156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Audrain-McGovern, C. Hughes Halbert, D. Rodriguez, L. H. Epstein, and K. P. Tercyak Predictors of Participation in a Smoking Cessation Program among Young Adult Smokers Cancer Epidemiol. Biomarkers Prev., March 1, 2007; 16(3): 617 - 619. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Carlsten and W. Burke Potential for Genetics to Promote Public Health: Genetics Research on Smoking Suggests Caution About Expectations JAMA, November 22, 2006; 296(20): 2480 - 2482. [Full Text] [PDF]
|
|
|
|
|
|
C. H. Halbert, O. H. Gandy Jr., A. Collier, and L. Shaker Intentions to Participate in Genetics Research among African American Smokers Cancer Epidemiol. Biomarkers Prev., January 1, 2006; 15(1): 150 - 153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. McBride, I. M. Lipkus, D. Jolly, and P. Lyna Interest in Testing for Genetic Susceptibility to Lung Cancer among Black College Students "At Risk" of Becoming Cigarette Smokers Cancer Epidemiol. Biomarkers Prev., December 1, 2005; 14(12): 2978 - 2981. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Sanderson and J. Wardle Will Genetic Testing for Complex Diseases Increase Motivation to Quit Smoking? Anticipated Reactions in a Survey of Smokers Health Educ Behav, October 1, 2005; 32(5): 640 - 653. [Abstract] [PDF]
|
|
|
|
|
|
C. Wang, D. J. Bowen, and S. L. R. Kardia Research and Practice Opportunities at the Intersection of Health Education, Health Behavior, and Genomics Health Educ Behav, October 1, 2005; 32(5): 686 - 701. [Abstract] [PDF]
|
|
|
|
 |
|
 D. A. Kaminsky, T. W. Marcy, and D. Gorecka COPD and Smoking Cessation Motivation Chest, May 1, 2004; 125(5): 1958 - 1959. [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. Sabichi, M.-F. Demierre, E. T. Hawk, C. E. Lerman, and S. M. Lippman Frontiers in Cancer Prevention Research Cancer Res., September 15, 2003; 63(18): 5649 - 5655. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Cell Growth & Differentiation |
