| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Short Communications |
Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii 96813
Oxidative stress may be one mechanism by which tobacco smoke causes lung cancer. A common oxidative damage to DNA is the highly mutagenic 7,8-dihydro-8-oxoguanine adduct, which can be repaired by 8-oxoguanine glycosylase I (OGG1). A Ser326Cys substitution polymorphism in the hOGG1 gene has been suggested, based on in vitro data, to reduce the activity of the enzyme. We tested the association of this polymorphism with lung cancer in a population-based, case control study of 298 cases and 405 controls of Caucasian, Japanese, or Native Hawaiian ancestry in Hawaii. Subjects were genotyped with a PCR-RFLP assay, and odds ratios were estimated by logistic regression after adjustment for other observed risk factors, including smoking and vegetable intake. We found marked differences in the frequencies of the hOGG1 Cys variant allele among ethnic groups (45% in Hawaiians, 42% in Japanese, and 22% in Caucasians). The homozygous Cys/Cys genotype was also found to be more common in cases than controls (P = 0.008), with an odds ratio of 2.1 (95% confidence interval: 1.2–3.7) for this genotype compared with the Ser/Ser genotype. Heterozygous individuals were not at increased risk. This association with the Cys/Cys genotype was observed for each sex, ethnic group, and lung cancer cell type. There was also the suggestion that vegetable intake may not be protective against lung cancer among subjects with the Cys/Cys genotype. These data suggest that the presence of two hOGG1 326Cys alleles confers a 2-fold increased risk of lung cancer. Additional studies need to be conducted to confirm this association.
This article has been cited by other articles:
|
|
 |
|
  K. Arizono, Y. Osada, and Y. Kuroda DNA Repair Gene hOGG1 Codon 326 and XRCC1 Codon 399 Polymorphisms and Bladder Cancer Risk in a Japanese Population Jpn. J. Clin. Oncol., March 1, 2008; 38(3): 186 - 191. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-A. Yoon, S. Park, B. Hwangbo, H. D. Shin, H. S. Cheong, H.-R. Shin, and J. S. Lee Genetic polymorphisms in the Rb-binding zinc finger gene RIZ and the risk of lung cancer Carcinogenesis, September 1, 2007; 28(9): 1971 - 1977. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Landi, F. Gemignani, F. Canzian, V. Gaborieau, R. Barale, D. Landi, N. Szeszenia-Dabrowska, D. Zaridze, J. Lissowska, P. Rudnai, et al. DNA Repair and Cell Cycle Control Genes and the Risk of Young-Onset Lung Cancer. Cancer Res., November 15, 2006; 66(22): 11062 - 11069. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-A. Yoon, B. Hwangbo, I.-J. Kim, S. Park, H. S. Kim, H. J. Kee, J. E. Lee, Y. K. Jang, J.-G. Park, and J. S. Lee Novel polymorphisms in the SUV39H2 histone methyltransferase and the risk of lung cancer Carcinogenesis, November 1, 2006; 27(11): 2217 - 2222. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. L. Nock, M. S. Cicek, L. Li, X. Liu, B. A. Rybicki, A. Moreira, S. J. Plummer, G. Casey, and J. S. Witte Polymorphisms in estrogen bioactivation, detoxification and oxidative DNA base excision repair genes and prostate cancer risk Carcinogenesis, September 1, 2006; 27(9): 1842 - 1848. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Hill and M. K. Evans Dimerization and opposite base-dependent catalytic impairment of polymorphic S326C OGG1 glycosylase Nucleic Acids Res., March 20, 2006; 34(5): 1620 - 1632. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Hung, J. Hall, P. Brennan, and P. Boffetta Genetic Polymorphisms in the Base Excision Repair Pathway and Cancer Risk: A HuGE Review Am. J. Epidemiol., November 15, 2005; 162(10): 925 - 942. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Matullo, M. Berwick, and P. Vineis Gene-Environment Interactions: How Many False Positives? J Natl Cancer Inst, April 20, 2005; 97(8): 550 - 551. [Full Text] [PDF]
|
|
|
|
|
|
R. J. Hung, P. Brennan, F. Canzian, N. Szeszenia-Dabrowska, D. Zaridze, J. Lissowska, P. Rudnai, E. Fabianova, D. Mates, L. Foretova, et al. Large-Scale Investigation of Base Excision Repair Genetic Polymorphisms and Lung Cancer Risk in a Multicenter Study J Natl Cancer Inst, April 20, 2005; 97(8): 567 - 576. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Hu, M. P. McDermott, and S. A. Ahrendt The p53 Codon 72 Proline Allele Is Associated with p53 Gene Mutations in Non-Small Cell Lung Cancer Clin. Cancer Res., April 1, 2005; 11(7): 2502 - 2509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Luna, V. Rolseth, G. A. Hildrestrand, M. Otterlei, F. Dantzer, M. Bjoras, and E. Seeberg Dynamic relocalization of hOGG1 during the cell cycle is disrupted in cells harbouring the hOGG1-Cys326 polymorphic variant Nucleic Acids Res., March 30, 2005; 33(6): 1813 - 1824. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Speina, K. D. Arczewska, D. Gackowski, M. Zielinska, A. Siomek, J. Kowalewski, R. Olinski, B. Tudek, and J. T. Kusmierek Contribution of hMTH1 to the Maintenance of 8-Oxoguanine Levels in Lung DNA of Non-Small-Cell Lung Cancer Patients J Natl Cancer Inst, March 2, 2005; 97(5): 384 - 395. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Lan, J. L. Mumford, M. Shen, D. M. DeMarini, M. R. Bonner, X. He, M. Yeager, R. Welch, S. Chanock, L. Tian, et al. Oxidative damage-related genes AKR1C3 and OGG1 modulate risks for lung cancer due to exposure to PAH-rich coal combustion emissions Carcinogenesis, November 1, 2004; 25(11): 2177 - 2181. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Morgenstern Oxidative Stress and Human Genetic Variation J. Nutr., November 1, 2004; 134(11): 3173S - 3174S. [Full Text] [PDF]
|
|
|
|
|
|
A. R. Trzeciak, S. G. Nyaga, P. Jaruga, A. Lohani, M. Dizdaroglu, and M. K. Evans Cellular repair of oxidatively induced DNA base lesions is defective in prostate cancer cell lines, PC-3 and DU-145 Carcinogenesis, August 1, 2004; 25(8): 1359 - 1370. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Zhang, Q. Shi, L.-E Wang, E. M. Sturgis, M. R. Spitz, A. K. El-Naggar, W. K. Hong, and Q. Wei No Association between hOGG1 Ser326Cys Polymorphism and Risk of Squamous Cell Carcinoma of the Head and Neck Cancer Epidemiol. Biomarkers Prev., June 1, 2004; 13(6): 1081 - 1083. [Full Text] [PDF]
|
|
|
|
|
|
Y. Xie, H. Yang, C. Cunanan, K. Okamoto, D. Shibata, J. Pan, D. E. Barnes, T. Lindahl, M. McIlhatton, R. Fishel, et al. Deficiencies in Mouse Myh and Ogg1 Result in Tumor Predisposition and G to T Mutations in Codon 12 of the K-Ras Oncogene in Lung Tumors Cancer Res., May 1, 2004; 64(9): 3096 - 3102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhu, M. R. Spitz, C. I. Amos, J. Lin, M. B. Schabath, and X. Wu An Evolutionary Perspective on Single-Nucleotide Polymorphism Screening in Molecular Cancer Epidemiology Cancer Res., March 15, 2004; 64(6): 2251 - 2257. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Gackowski, E. Speina, M. Zielinska, J. Kowalewski, R. Rozalski, A. Siomek, T. Paciorek, B. Tudek, and R. Olinski Products of Oxidative DNA Damage and Repair as Possible Biomarkers of Susceptibility to Lung Cancer Cancer Res., August 15, 2003; 63(16): 4899 - 4902. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Yamane, K. Shinmura, N. Sunaga, T. Saitoh, S. Yamaguchi, Y. Shinmura, K. Yoshimura, H. Murakami, Y. Nojima, T. Kohno, et al. Suppressive activities of OGG1 and MYH proteins against G:C to T:A mutations caused by 8-hydroxyguanine but not by benzo[a]pyrene diol epoxide in human cells in vivo Carcinogenesis, June 1, 2003; 24(6): 1031 - 1037. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. R. Halford, A. J. Rowan, L. Lipton, O. M. Sieber, K. Pack, H. J. W. Thomas, S. V. Hodgson, W. F. Bodmer, and I. P. M. Tomlinson Germline Mutations but Not Somatic Changes at the MYH Locus Contribute to the Pathogenesis of Unselected Colorectal Cancers Am. J. Pathol., May 1, 2003; 162(5): 1545 - 1548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. Goode, C. M. Ulrich, and J. D. Potter Polymorphisms in DNA Repair Genes and Associations with Cancer Risk Cancer Epidemiol. Biomarkers Prev., December 1, 2002; 11(12): 1513 - 1530. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Cell Growth & Differentiation |
