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A Prospective Study on Supplemental Vitamin E Intake and Risk of Colon Cancer in Women and Men¹

Departments of Nutrition [K. W., W. C. W., J. M. C., E. B. R., E. L. G.], and of Epidemiology [W. C. W., J. M. C., G. A. C. E. B. R., E. L. G.], Harvard School of Public Health, Boston, Massachusetts 02115; Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115 [W. C. W., C. S. F., G. A. C., E. B. R., E. L. G.]; and Dana-Farber Cancer Institute, Division of Medical Oncology, Boston, Massachusetts 02115 [C. S. F.]

We conducted a prospective study on the association between supplemental vitamin E and colon cancer in 87,998 females from the Nurses’ Health Study and 47, 344 males from the Health Professionals Follow-up Study. There was some suggestion that men with supplemental vitamin E intake of 300 IU/day or more may be at lower risk for colon cancer when compared with never users [multivariate relative risk (RR), 300–500 IU/day versus never users, 0.73 (95% confidence interval (CI), 0.52–1.03); 600 IU/day versus never users = 0.70 (95% CI = 0.38–1.29)], but CIs included 1. In women, there was no evidence for an inverse association between vitamin E supplementation and risk of colon cancer. Our findings do not provide consistent support for an inverse association between supplemental vitamin E and colon cancer risk. Considering the paucity of epidemiological data on this association, further studies of vitamin E and colon cancer are warranted.

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