This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Park, J. Y. Articles by Jung, T. H. Search for Related Content PubMed PubMed Citation Articles by Park, J. Y. Articles by Jung, T. H.

Polymorphisms of the DNA Repair Gene Xeroderma Pigmentosum Group A and Risk of Primary Lung Cancer¹

Department of Internal Medicine, Kyungpook National University Hospital, Taegu 700-412 [J. Y. P., S. H. P., S. I. C., C. H. K., T. H. J.]; Cancer Research Institute, Kyungpook National University Hospital, Taegu 700-412 [J. Y. P., J. E. C., S. Y. L.]; Department of Biochemistry, School of Medicine, Kyungpook National University, Taegu 700-422 [J. Y. P., H-S. J., R. W. P., I-S. K.]; Department of Internal Medicine, School of Medicine, Keimyung University, Taegu 700-712 [J-H. P.]; and Department of Preventive Medicine, School of Medicine, Kyungpook National University, Taegu 700–422 [S. K.], Korea

Polymorphisms in DNA repair genes may be associated with differences in the repair capacity of DNA damage and may influence an individual’s susceptibility to smoking-related cancer. We investigated the association between two polymorphisms of the DNA repair gene XPA and risk of lung cancer in the Korean population. Two XPA polymorphisms (A23G and G709A) were typed in 265 lung cancer patients and 185 healthy controls who were frequency-matched on age and sex. The XPA G709A polymorphism was not detected in cases and controls. The XPA 23 GG genotype was associated with a significantly decreased risk for lung cancer [odds ratio (OR), 0.56; 95% confidence interval (CI), 0.35–0.90] when the combined AA and AG genotype was used as the reference. The reduction in risk for the XPA 23 GG genotype was significant in males (OR, 0.51; 95% CI, 0.30–0.86), younger individuals (OR, 0.39; 95% CI, 0.19–0.80), and current smokers (OR, 0.46; 95% CI, 0.25–0.83). These results suggest that the XPA A23G polymorphism contributes to genetic susceptibility for lung cancer.

This article has been cited by other articles:

				J. Lin, G. E. Swan, P. G. Shields, N. L. Benowitz, J. Gu, C. I. Amos, M. de Andrade, M. R. Spitz, and X. Wu Mutagen Sensitivity and Genetic Variants in Nucleotide Excision Repair Pathway: Genotype-Phenotype Correlation Cancer Epidemiol. Biomarkers Prev., October 1, 2007; 16(10): 2065 - 2071. [Abstract] [Full Text] [PDF]

				J. An, Z. Liu, Z. Hu, G. Li, L.-E Wang, E. M. Sturgis, A. K. El-Naggar, M. R. Spitz, and Q. Wei Potentially Functional Single Nucleotide Polymorphisms in the Core Nucleotide Excision Repair Genes and Risk of Squamous Cell Carcinoma of the Head and Neck Cancer Epidemiol. Biomarkers Prev., August 1, 2007; 16(8): 1633 - 1638. [Abstract] [Full Text] [PDF]

				Y. Wang, M. R. Spitz, J. J. Lee, M. Huang, S. M. Lippman, and X. Wu Nucleotide Excision Repair Pathway Genes and Oral Premalignant Lesions Clin. Cancer Res., June 15, 2007; 13(12): 3753 - 3758. [Abstract] [Full Text] [PDF]

				J. Hall, M. Hashibe, P. Boffetta, V. Gaborieau, N. Moullan, A. Chabrier, D. Zaridze, O. Shangina, N. Szeszenia-Dabrowska, D. Mates, et al. The association of sequence variants in DNA repair and cell cycle genes with cancers of the upper aerodigestive tract Carcinogenesis, March 1, 2007; 28(3): 665 - 671. [Abstract] [Full Text] [PDF]

				M. C. Shin, S. J. Lee, J. E. Choi, S. I. Cha, C. H. Kim, W. K. Lee, S. Kam, Y. M. Kang, T. H. Jung, and J. Y. Park Glu346Lys Polymorphism in the Methyl-CpG Binding Domain 4 Gene and the Risk of Primary Lung Cancer Jpn. J. Clin. Oncol., August 1, 2006; 36(8): 483 - 488. [Abstract] [Full Text] [PDF]

				K. L. Miller, M. R. Karagas, P. Kraft, D. J. Hunter, P. J. Catalano, S. H. Byler, and H. H. Nelson XPA, haplotypes, and risk of basal and squamous cell carcinoma Carcinogenesis, August 1, 2006; 27(8): 1670 - 1675. [Abstract] [Full Text] [PDF]

				J. Y. Park, J. M. Park, J. S. Jang, J. E. Choi, K. M. Kim, S. I. Cha, C. H. Kim, Y. M. Kang, W. K. Lee, S. Kam, et al. Caspase 9 promoter polymorphisms and risk of primary lung cancer Hum. Mol. Genet., June 15, 2006; 15(12): 1963 - 1971. [Abstract] [Full Text] [PDF]

				M. Dusinska, Z. Dzupinkova, L. Wsolova, V. Harrington, and A. R. Collins Possible involvement of XPA in repair of oxidative DNA damage deduced from analysis of damage, repair and genotype in a human population study Mutagenesis, May 1, 2006; 21(3): 205 - 211. [Abstract] [Full Text] [PDF]

				C. Y. Jung, J. E. Choi, J. M. Park, M. H. Chae, H.-G. Kang, K. M. Kim, S. J. Lee, W. K. Lee, S. Kam, S. I. Cha, et al. Polymorphisms in the hMSH2 Gene and the Risk of Primary Lung Cancer. Cancer Epidemiol. Biomarkers Prev., April 1, 2006; 15(4): 762 - 768. [Abstract] [Full Text] [PDF]

				J.-S. Jang, S. J. Lee, J. E. Choi, S. I. Cha, E. B. Lee, T. I. Park, C. H. Kim, W. K. Lee, S. Kam, J.-Y. Choi, et al. Methyl-CpG Binding Domain 1 Gene Polymorphisms and Risk of Primary Lung Cancer Cancer Epidemiol. Biomarkers Prev., November 1, 2005; 14(11): 2474 - 2480. [Abstract] [Full Text] [PDF]

				J. M. Weiss, N. S. Weiss, C. M. Ulrich, J. A. Doherty, L. F. Voigt, and C. Chen Interindividual Variation in Nucleotide Excision Repair Genes and Risk of Endometrial Cancer Cancer Epidemiol. Biomarkers Prev., November 1, 2005; 14(11): 2524 - 2530. [Abstract] [Full Text] [PDF]

				S. J. Lee, H.-S. Jeon, J.-S. Jang, S. H. Park, G. Y. Lee, B.-H. Lee, C. H. Kim, Y. M. Kang, W. K. Lee, S. Kam, et al. DNMT3B polymorphisms and risk of primary lung cancer Carcinogenesis, February 1, 2005; 26(2): 403 - 409. [Abstract] [Full Text] [PDF]

				D. Liu, S. J. O'Day, D. Yang, P. Boasberg, R. Milford, T. Kristedja, S. Groshen, and J. Weber Impact of Gene Polymorphisms on Clinical Outcome for Stage IV Melanoma Patients Treated with Biochemotherapy: An Exploratory Study Clin. Cancer Res., February 1, 2005; 11(3): 1237 - 1246. [Abstract] [Full Text] [PDF]

				S. Pavanello, A. Pulliero, E. Siwinska, D. Mielzynska, and E. Clonfero Reduced nucleotide excision repair and GSTM1-null genotypes influence anti-B[a]PDE-DNA adduct levels in mononuclear white blood cells of highly PAH-exposed coke oven workers Carcinogenesis, January 1, 2005; 26(1): 169 - 175. [Abstract] [Full Text] [PDF]

				D. Butkiewicz, O. Popanda, A. Risch, L. Edler, H. Dienemann, V. Schulz, K. Kayser, P. Drings, H. Bartsch, and P. Schmezer Association between the Risk for Lung Adenocarcinoma and a (-4) G-to-A Polymorphism in the XPA Gene Cancer Epidemiol. Biomarkers Prev., December 1, 2004; 13(12): 2242 - 2246. [Abstract] [Full Text] [PDF]

				O. Popanda, T. Schattenberg, C. T. Phong, D. Butkiewicz, A. Risch, L. Edler, K. Kayser, H. Dienemann, V. Schulz, P. Drings, et al. Specific combinations of DNA repair gene variants and increased risk for non-small cell lung cancer Carcinogenesis, December 1, 2004; 25(12): 2433 - 2441. [Abstract] [Full Text] [PDF]

				H.-S. Jeon, K. M. Kim, S. H. Park, S. Y. Lee, J. E. Choi, G. Y. Lee, S. Kam, R. W. Park, I.-S. Kim, C. H. Kim, et al. Relationship between XPG codon 1104 polymorphism and risk of primary lung cancer Carcinogenesis, October 1, 2003; 24(10): 1677 - 1681. [Abstract] [Full Text] [PDF]

				J. E. Choi, S. H. Park, H.-S. Jeon, K. M. Kim, G. Y. Lee, R. W. Park, S. Kam, I.-S. Kim, C. H. Kim, S. H. Jheon, et al. No Association between Haplotypes of Three Variants (Codon 81, 284, and 762) in Poly(ADP-ribose) Polymerase Gene and Risk of Primary Lung Cancer Cancer Epidemiol. Biomarkers Prev., September 1, 2003; 12(9): 947 - 949. [Full Text] [PDF]

				X. Wu, H. Zhao, Q. Wei, C. I. Amos, K. Zhang, Z. Guo, Y. Qiao, W. K. Hong, and M. R. Spitz XPA polymorphism associated with reduced lung cancer risk and a modulating effect on nucleotide excision repair capacity Carcinogenesis, March 1, 2003; 24(3): 505 - 509. [Abstract] [Full Text] [PDF]