| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Department of Preventive Medicine, Northwestern University Medical School [S. M. G., P. H. G., L. C., K. L.], Department of Medicine, Center for Endocrinology, Metabolism and Molecular Medicine, Northwestern University Medical School [P. K.], and The Robert H. Lurie Comprehensive Cancer Center, Northwestern University [S. M. G., P. H. G., P. K.], Chicago, Illinois 60611, and Department of Obstetrics and Gynecology, University of Massachusetts, Worcester, Massachusetts 01655 [C. L.]
Serum testosterone concentration appears to be higher in black men than white men, particularly at younger ages. The higher incidence of prostate cancer in blacks has been attributed, at least in part, to this difference. Other factors associated with androgen levels in men include age and obesity. However, most of the studies of adult androgen levels are limited by their cross-sectional design. We conducted longitudinal analyses (Generalized Estimating Equation) of the associations of age, body mass index (BMI), and waist circumference with total and free testosterone and sex hormone-binding globulin (SHBG) concentrations during an 8-year period and compared these hormonal factors between black (n = 483) and white (n = 695) male participants of the Coronary Artery Risk Development in Young Adults (CARDIA) Study. For men ages 24 years and older at the time of the first hormone measurement, increasing age was associated with a statistically significant decrease in serum total and free testosterone and an increase in SHBG (P < 0.05). BMI and waist circumference were inversely associated with total testosterone and SHBG, but only BMI was inversely associated with free testosterone. After adjustment for age and BMI, total testosterone was higher in blacks (0.21 ng/ml; P = 0.028) than whites, an approximately 3% difference. However, after further adjustment for waist circumference, there was no black-white difference (0.05 ng/ml; P = 0.62). These results indicate that the age-associated decrease in circulating testosterone and increase in SHBG begin during the 3rd decade of life, and that increasing obesity, particularly central obesity, is associated with decreasing total testosterone and SHBG. Results also suggest that the previously observed difference in total testosterone between black and white men could be attributed, for the most part, to racial differences in abdominal obesity.
This article has been cited by other articles:
|
|
 |
|
  K. Rapp, J. Klenk, H. Ulmer, H. Concin, G. Diem, W. Oberaigner, and J. Schroeder Weight change and cancer risk in a cohort of more than 65 000 adults in Austria Ann. Onc., April 1, 2008; 19(4): 641 - 648. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Turk, P. Kopp, L. A. Colangelo, M. Urbanek, K. Wood, K. Liu, H. G. Skinner, and S. M. Gapstur Associations of Serum Sex Hormone Binding Globulin (SHBG) Levels with SHBG Gene Polymorphisms in the CARDIA Male Hormone Study Am. J. Epidemiol., February 15, 2008; 167(4): 412 - 418. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Y. Liu, J. Beilin, C. Meier, T. V. Nguyen, J. R. Center, P. J. Leedman, M. J. Seibel, J. A. Eisman, and D. J. Handelsman Age-Related Changes in Serum Testosterone and Sex Hormone Binding Globulin in Australian Men: Longitudinal Analyses of Two Geographically Separate Regional Cohorts J. Clin. Endocrinol. Metab., September 1, 2007; 92(9): 3599 - 3603. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Rohrmann, W. G. Nelson, N. Rifai, T. R. Brown, A. Dobs, N. Kanarek, J. D. Yager, and E. A. Platz Serum Estrogen, But Not Testosterone, Levels Differ between Black and White Men in a Nationally Representative Sample of Americans J. Clin. Endocrinol. Metab., July 1, 2007; 92(7): 2519 - 2525. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Rodriguez, S. J. Freedland, A. Deka, E. J. Jacobs, M. L. McCullough, A. V. Patel, M. J. Thun, and E. E. Calle Body Mass Index, Weight Change, and Risk of Prostate Cancer in the Cancer Prevention Study II Nutrition Cohort Cancer Epidemiol. Biomarkers Prev., January 1, 2007; 16(1): 63 - 69. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Litman, S. Bhasin, C. L. Link, A. B. Araujo, J. B. McKinlay, and for the Boston Area Community Health Survey Invest Serum Androgen Levels in Black, Hispanic, and White Men J. Clin. Endocrinol. Metab., November 1, 2006; 91(11): 4326 - 4334. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Qoubaitary, C. Meriggiola, C. M. Ng, L. Lumbreras, S. Cerpolini, G. Pelusi, P. D. Christensen, L. Hull, R. S. Swerdloff, and C. Wang Pharmacokinetics of Testosterone Undecanoate Injected Alone or in Combination With Norethisterone Enanthate in Healthy Men J Androl, November 1, 2006; 27(6): 853 - 867. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Wang, X. H. Wang, A. L. Nelson, K. K. Lee, Y. G. Cui, J. S. Tong, N. Berman, L. Lumbreras, A. Leung, L. Hull, et al. Levonorgestrel Implants Enhanced the Suppression of Spermatogenesis by Testosterone Implants: Comparison between Chinese and Non-Chinese Men J. Clin. Endocrinol. Metab., February 1, 2006; 91(2): 460 - 470. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Kaufman and A. Vermeulen The Decline of Androgen Levels in Elderly Men and Its Clinical and Therapeutic Implications Endocr. Rev., October 1, 2005; 26(6): 833 - 876. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Reinehr, G. de Sousa, C. L. Roth, and W. Andler Androgens before and after Weight Loss in Obese Children J. Clin. Endocrinol. Metab., October 1, 2005; 90(10): 5588 - 5595. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Cheng, M. C. Yu, W.-P. Koh, M. C. Pike, L. N. Kolonel, B. E. Henderson, and D. O. Stram Comparison of Prostate-Specific Antigen and Hormone Levels among Men in Singapore and the United States Cancer Epidemiol. Biomarkers Prev., July 1, 2005; 14(7): 1692 - 1696. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. R. Robinson, J. Stevens, M. D. Gammon, and E. M. John Obesity before Age 30 Years and Risk of Advanced Prostate Cancer Am. J. Epidemiol., June 15, 2005; 161(12): 1107 - 1114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Potischman, R. Troisi, R. Thadhani, R. N. Hoover, K. Dodd, W. W. Davis, P. M. Sluss, C.-C. Hsieh, and R. Ballard-Barbash Pregnancy Hormone Concentrations Across Ethnic Groups: Implications for Later Cancer Risk Cancer Epidemiol. Biomarkers Prev., June 1, 2005; 14(6): 1514 - 1520. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. Araujo, A. B. O'Donnell, D. J. Brambilla, W. B. Simpson, C. Longcope, A. M. Matsumoto, and J. B. McKinlay Prevalence and Incidence of Androgen Deficiency in Middle-Aged and Older Men: Estimates from the Massachusetts Male Aging Study J. Clin. Endocrinol. Metab., December 1, 2004; 89(12): 5920 - 5926. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Sharp, A. H. Cardy, S. C. Cotton, and J. Little CYP17 Gene Polymorphisms: Prevalence and Associations with Hormone Levels and Related Factors. A HuGE Review Am. J. Epidemiol., October 15, 2004; 160(8): 729 - 740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. de Kretser Is Spermatogenic Damage Associated with Leydig Cell Dysfunction? J. Clin. Endocrinol. Metab., July 1, 2004; 89(7): 3158 - 3160. [Full Text] [PDF]
|
|
|
|
|
|
S. Rohrmann, E. Smit, E. Giovannucci, and E. A. Platz Associations of Obesity with Lower Urinary Tract Symptoms and Noncancer Prostate Surgery in the Third National Health and Nutrition Examination Survey Am. J. Epidemiol., February 15, 2004; 159(4): 390 - 397. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. Amling, R. H. Riffenburgh, L. Sun, J. W. Moul, R. S. Lance, L. Kusuda, W. J. Sexton, D. W. Soderdahl, T. F. Donahue, J. P. Foley, et al. Pathologic Variables and Recurrence Rates As Related to Obesity and Race in Men With Prostate Cancer Undergoing Radical Prostatectomy J. Clin. Oncol., February 1, 2004; 22(3): 439 - 445. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Cell Growth & Differentiation |
