This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Gao, C. Articles by Sugimura, H. Search for Related Content PubMed PubMed Citation Articles by Gao, C. Articles by Sugimura, H.

Interaction between Cytochrome P-450 2E1 Polymorphisms and Environmental Factors with Risk of Esophageal and Stomach Cancers in Chinese¹

Division of Epidemiology, Cancer Research Institute of Jiangsu Province, Nanjing 210009, China [C. G., J. W., J. D., Y. L.]; Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan [T. T., K. T.]; First Department of Pathology, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan [Z. L., J. W., H. S.]; and Public Health Center of Huaian City, Huaian 221300, China [X. H., T. X.]

Because cytochrome P-450 2E1 (CYP2E1) is involved in metabolic activation of environmental chemical carcinogens, gene polymorphisms that alter its functions may be associated with cancer susceptibility. However, previous studies have revealed disconcordant results with regard to cancer risk. To investigate gene-environment interactions with the RsaI polymorphism of CYP2E1 in terms of risk of esophageal and stomach cancers, we conducted a case-control study with 93 esophageal and 98 stomach cancer cases and 196 population-based controls in a high-endemic area for these cancers of China. We assayed genomic DNA samples for RFLPs in the CYP2E1 by PCR amplification, followed by digestion with RsaI, and collected information on environmental factors by a questionnaire approach. Odds ratios were estimated with an unconditional logistic model, after adjustment for potential confounding factors. The proportional distribution of the homozygous common RsaI alleles did not differ between cancer cases of the esophagus (59.1%) and stomach (59.2%), and controls (61.7%). However, we found a significant positive interaction between the heterozygous and homozygous RsaI rare alleles and ever-smoking in the odds ratio for stomach cancer (P = 0.015). The interaction between the gene polymorphism and dietary factors, such as garlic consumption, was not observed in both cancer cases. These results suggest that gene-environment interactions between the CYP2E1 polymorphism and smoking may have the potential to alter the susceptibility for cancer development in the stomach.

This article has been cited by other articles:

				A. Rossini, D.C.M. Rapozo, S.C. Soares Lima, D.P. Guimaraes, M.A. Ferreira, R. Teixeira, C.D.P. Kruel, S.G.S. Barros, N.A. Andreollo, R. Acatauassu, et al. Polymorphisms of GSTP1 and GSTT1, but not of CYP2A6, CYP2E1 or GSTM1, modify the risk for esophageal cancer in a western population Carcinogenesis, December 1, 2007; 28(12): 2537 - 2542. [Abstract] [Full Text] [PDF]

				S. Boccia, A. D. Lauretis, F. Gianfagna, C. M.v. Duijn, and G. Ricciardi CYP2E1PstI/RsaI polymorphism and interaction with tobacco, alcohol and GSTs in gastric cancer susceptibility: a meta-analysis of the literature Carcinogenesis, January 1, 2007; 28(1): 101 - 106. [Abstract] [Full Text] [PDF]

				J. A. Milner Preclinical Perspectives on Garlic and Cancer J. Nutr., March 1, 2006; 136(3): 827S - 831S. [Abstract] [Full Text] [PDF]

				W.-c. You, J.-Y. Hong, L. Zhang, K.-f. Pan, D. Pee, J.-y. Li, J.-l. Ma, N. Rothman, N. Caporaso, J. F. Fraumeni Jr., et al. Genetic Polymorphisms of CYP2E1, GSTT1, GSTP1, GSTM1, ALDH2, and ODC and the Risk of Advanced Precancerous Gastric Lesions in a Chinese Population Cancer Epidemiol. Biomarkers Prev., February 1, 2005; 14(2): 451 - 458. [Abstract] [Full Text] [PDF]