This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hall, H. I. Articles by Weir, H. K. Search for Related Content PubMed PubMed Citation Articles by Hall, H. I. Articles by Weir, H. K.

Second Primary Ovarian Cancer Among Women Diagnosed Previously with Cancer

Cancer Surveillance Branch, Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Atlanta, Georgia 30341

This study assessed the risk of second primary ovarian cancer among United States women diagnosed previously with invasive cancer. We analyzed data from cancer registries participating in the Surveillance, Epidemiology, and End Results program for women diagnosed with invasive cancer between 1973 and 1996. We calculated the risk [observed (O)/expected numbers (E)] of second primary ovarian cancer by cancer site and age at diagnosis of first primary cancer (<50 years and 50 years), race (all, white, and black), and years since first cancer (0–4, 5–9, 10–14, and 15–24 years). Statistical tests and 95% confidence intervals (CI) assumed a Poisson distribution. A significantly increased risk of ovarian cancer was found for women who were aged <50 years at diagnosis with melanoma (O/E = 3.5, 95% CI = 2.1–5.5) or cancer of the breast (O/E = 6.0, 95% CI = 4.9–7.2), cervix (O/E = 4.2, 95% CI = 2.6–6.3), corpus uteri (O/E = 11.9, 95% CI = 7.3–18.4), colon (O/E = 17.9, 95% CI = 11.1–27.3), or ovary (O/E = 4.9, 95% CI = 2.7–8.2). No increased risk was found for women aged 50 years. Ovarian cancer risk remained elevated after these first primary cancers 5–9 years after diagnosis; for breast and colon cancer, risk remained elevated 15–24 years after diagnosis. Women 50 years at diagnosis with melanoma or cancer of the cervix, corpus uteri, ovary, rectum, or lung and bronchus were at a decreased risk for second primary ovarian cancer. Ovarian cancer risk is higher than expected for women who were diagnosed with certain types of cancer at <50 years of age.

This article has been cited by other articles:

				K. Burry, J. M. Cain, L. Gilbert, S. Krishnamurthy, S. L. Tan, E. L. Franco, J. V. Lacey, Jr, P. J. Mink, J. H. Lubin, M. E. Sherman, et al. Estrogen Replacement Therapy and Risk of Ovarian Cancer in Postmenopausal Women JAMA, November 27, 2002; 288(20): 2538 - 2539. [Full Text] [PDF]