This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wang, J.-S. Articles by Groopman, J. D. Search for Related Content PubMed PubMed Citation Articles by Wang, J.-S. Articles by Groopman, J. D.

Hepatocellular Carcinoma and Aflatoxin Exposure in Zhuqing Village, Fusui County, People’s Republic of China¹

Department of Environmental Health Sciences, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205 [J-S. W., G. S., X. H., T. W. K., J. D. G.]; Guangxi Cancer Institute, Nanning, Guangxi, People’s Republic of China [T. H., J. S.]; Fusui Liver Cancer Institute, Fusui, Guangxi, People’s Republic of China [F. L., Z. W., Y. L.]; and Shanghai Cancer Institute, Shanghai, People’s Republic of China [H. L., S-Y. K., G-S. Q.].

Hepatocellular carcinoma (HCC) is a common cause of cancer morbidity and mortality in Asia and Africa. Epidemiological studies have found that dietary exposure to aflatoxin B₁ (AFB₁) and chronic infection with hepatitis B virus are two major risk factors for HCC. We have collated the incidence and mortality data of malignant tumors from 1973 to 1999 in Zhuqing Village, Fusui County, an area with very high HCC rates, and found that this cancer accounted for 64% of the total cancer incidence. Dietary intake of AFB₁ was monitored for 1 week in a study group consisting of 15 males and 14 females from different households in this village. Four of 29 participants (13.8%) and 3 of 15 (20%) male participants were hepatitis B virus surface antigen positive. AFB₁ was detectable in 76.7% (23 of 30) of ground corn samples (range, 0.4–128.1 ppb), 66.7% (20 of 30) of cooking peanut oil samples (range, 0.1–52.5 ppb), and 23.3% (7 of 30) of rice samples (range, 0.3–2.0 ppb) collected from each household. Mean levels of serum AFB₁-albumin adducts in this group were 1.24 ± 0.31 pmol/mg of albumin at the beginning of the study and 1.21 ± 0.19 pmol/mg of albumin at the end of the period. Urinary AFB₁ metabolites were detectable in 88.9% (24 of 27) samples (range, 0.9–3569.7 ng/24-h urine). These data provide the exposure and disease risk information for establishing intervention studies to diminish the impact of aflatoxin exposure in this high-risk population.

This article has been cited by other articles:

				L. Tang, M. Tang, L. Xu, H. Luo, T. Huang, J. Yu, L. Zhang, W. Gao, S. B. Cox, and J.-S. Wang Modulation of aflatoxin biomarkers in human blood and urine by green tea polyphenols intervention Carcinogenesis, February 1, 2008; 29(2): 411 - 417. [Abstract] [Full Text] [PDF]

				K. G. Murugavel, P. P. Naranatt, E. M. Shankar, S. Mathews, K. Raghuram, P. Rajasambandam, V. Jayanthi, R. Surendran, A. Murali, U. Srinivas, et al. Prevalence of aflatoxin B1 in liver biopsies of proven hepatocellular carcinoma in India determined by an in-house immunoperoxidase test J. Med. Microbiol., November 1, 2007; 56(11): 1455 - 1459. [Abstract] [Full Text] [PDF]

				G.R. OBrian, D.R. Georgianna, J.R. Wilkinson, J. Yu, H.K. Abbas, D. Bhatnagar, T.E. Cleveland, W. Nierman, and G.A. Payne The effect of elevated temperature on gene transcription and aflatoxin biosynthesis Mycologia, March 1, 2007; 99(2): 232 - 239. [Abstract] [Full Text] [PDF]

				C.-K. Chang, G. Astrakianakis, D. B Thomas, N. S Seixas, R. M Ray, D. L. Gao, K. J Wernli, E D. Fitzgibbons, T. L Vaughan, and H. Checkoway Occupational exposures and risks of liver cancer among Shanghai female textile workers--a case-cohort study Int. J. Epidemiol., April 1, 2006; 35(2): 361 - 369. [Abstract] [Full Text] [PDF]

				Y. Jiang, P. E. Jolly, W. O. Ellis, J.-S. Wang, T. D. Phillips, and J. H. Williams Aflatoxin B1 albumin adduct levels and cellular immune status in Ghanaians Int. Immunol., June 1, 2005; 17(6): 807 - 814. [Abstract] [Full Text] [PDF]

				J. H Williams, T. D Phillips, P. E Jolly, J. K Stiles, C. M Jolly, and D. Aggarwal Human aflatoxicosis in developing countries: a review of toxicology, exposure, potential health consequences, and interventions Am. J. Clinical Nutrition, November 1, 2004; 80(5): 1106 - 1122. [Abstract] [Full Text] [PDF]

				D. M. Hinton, M. J. Myers, R. A. Raybourne, S. Francke-Carroll, R. E. Sotomayor, J. Shaddock, A. Warbritton, and M. W. Chou Immunotoxicity of Aflatoxin B1 in Rats: Effects on Lymphocytes and the Inflammatory Response in a Chronic Intermittent Dosing Study Toxicol. Sci., June 1, 2003; 73(2): 362 - 377. [Abstract] [Full Text] [PDF]

				C. Wang, T. K. Bammler, and D. L. Eaton Complementary DNA Cloning, Protein Expression, and Characterization of Alpha-Class GSTs from Macaca fascicularis Liver Toxicol. Sci., November 1, 2002; 70(1): 20 - 26. [Abstract] [Full Text] [PDF]

				A. A. Evans, G. Chen, E. A. Ross, F.-M. Shen, W.-Y. Lin, and W. T. London Eight-Year Follow-Up of the 90,000-Person Haimen City Cohort: I. Hepatocellular Carcinoma Mortality, Risk Factors, and Gender Differences Cancer Epidemiol. Biomarkers Prev., April 1, 2002; 11(4): 369 - 376. [Abstract] [Full Text] [PDF]