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Lack of Interaction between Asbestos Exposure and Glutathione S-Transferase M1 and T1 Genotypes in Lung Carcinogenesis

INSERM U170, 94807 Villejuif, France [I. S.]; International Agency for Research on Cancer, 69008 Lyon, France [P. B.]; Finnish Institute of Occupational Health, FIN-00250 Helsinki, Finland [S. A., A. H.]; INSERM U351, 94805 Villejuif, France [S. B.]; National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709 [S. L.]; and Ospedale Policlinico IRCCS, University of Milan, 20122 Milan, Italy [E. T.]

An interaction between occupational carcinogens and genetic susceptibility factors in determining individual lung cancer risk is biologically plausible, but the interpretation of available studies are limited by the small number of exposed subjects. We selected from the international database on Genetic Susceptibility and Environmental Carcinogens the studies of lung cancer that included information on metabolic polymorphisms and occupational exposures. Adequate data were available for asbestos exposure and GSTM1 (five studies) and GSTT1 (three studies) polymorphisms. For GSTM1, the pooled analysis included 651 cases and 983 controls. The odds ratio (OR) of lung cancer was 2.0 [95% confidence interval (CI) 1.4–2.7] for asbestos exposure and 1.1 (95% CI 0.9–1.4) for GSTM1-null genotype. The OR of interaction between asbestos and GSTM1 polymorphism was 1.1 (95% CI 0.6–2.1) based on 54 cases and 53 controls who were asbestos exposed and GSTM1 null. The case-only approach, which was based on 869 lung cancer cases and had an 80% power to detect an OR of interaction of 1.56, also provided lack of evidence of interaction. The analysis of possible interaction between GSTT1 polymorphism and asbestos exposure in relation to lung cancer was based on 619 cases. The prevalence OR of GSTT1-null genotype and asbestos exposure was 1.1 (95% CI 0.6–2.0). Our results do not support the hypothesis that the risk of lung cancer after asbestos exposure differs according to GSTM1 genotype. The low statistical power of the pooled analysis for GSTT1 genotypes hampered any firm conclusion. No adequate data were available to assess other interactions between occupational exposures and metabolic polymorphisms.

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