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HLA Class II DR-DQ and Increased Risk of Cervical Cancer among Senegalese Women¹

Departments of Pathology, School of Medicine [N. B. K.], Epidemiology [P. L., L. A. K., C. W. C., S. E. H.], and Biostatistics [J. P. H.], University of Washington, Seattle, Washington 98195; Roche Molecular Systems, Department of Human Genetics, Alameda, California 94501 [R. J. A.]; and Institut du Cancer, Dantec Hospital, Dakar, Senegal [P. T., A. D.]

To examine Senegalese women to confirm and extend associations between HLA class II types and cervical cancer previously observed among African-American, Caucasian, Hispanic, and Japanese ethnic populations, 55 Senegalese women with invasive cervical carcinoma were compared with age-matched (human papillomavirus) HPV-positive (n = 83) and HPV-negative (n = 107) control women. PCR-based HPV and HLA typing methods were used. Data were analyzed using a global randomization test and conditional logistic regression. Although this study failed to confirm a previously reported association between cervical cancer and DQB1*03 alleles, the DRB1*1101-DQB1*0301 haplotype was detected more frequently among cervical carcinoma cases than among controls (adjusted odds ratio, 2.6; 95% confidence interval, 1.0–7.1). Furthermore, as reported by others, we observed a negative association of borderline statistical significance between DRB1*13 and cervical carcinoma (adjusted odds ratio, 0.5; 95% confidence interval, 0.2–1.1). Observations from this study confirm earlier findings of a negative association between DRB1*13 and cervical cancer and suggest that specific DRB1-DQB1 haplotype combinations, rather than individual DQB1*03 alleles, increase the risk for cervical cancer.

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