This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hunt, J. D. Articles by Fontham, E. T. H. Search for Related Content PubMed PubMed Citation Articles by Hunt, J. D. Articles by Fontham, E. T. H.

KRAS Mutations Are Not Predictive for Progression of Preneoplastic Gastric Lesions¹

Departments of Biochemistry and Molecular Biology [J. D. H., A. S., A. T. G.], Pathology [R. M., P. C.], and Public Health and Preventive Medicine [E. T. H. F.], and the Stanley S. Scott Cancer Center [J. D. H., R. M., P. C., E. T. H. F.], Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112

Individuals with atrophic gastritis (n = 863) were recruited to participate in a chemoprevention trial in Nariño, Columbia. The volunteers were randomly assigned to intervention therapies, which included antibiotic treatment for Helicobacter pylori infection, and then daily dietary supplementation with antioxidant micronutrients in a 2³factorial design. Biopsies were obtained according to a specified protocol from designated areas in the stomach for each individual at baseline (before intervention therapy), at year 3, and at year 6. A systematic sample of 160 participants was selected from each of the eight treatment combinations, and the first exon of KRAS was examined for mutations. At year 3, the data indicated that individuals with KRAS mutations in their baseline premalignant stomach biopsies were 3.74 times as likely to progress to a higher premalignant stage than those who lacked baseline mutations (P = 0.04; C. Gong et al., Cancer Epidemiol. Biomark. Prev. 8:167–171, 1999). However, after 6 years, baseline KRAS mutations failed to predict histological progression. Also, KRAS mutation in 72-month biopsies did not predict histological progression.

This article has been cited by other articles:

				J. G. Fox and T. C. Wang Helicobacter pylori -- Not a Good Bug after All N. Engl. J. Med., September 13, 2001; 345(11): 829 - 832. [Full Text] [PDF]