CEBP -- Mechanic et al. 16 (2): 214 Table BL6

Table 6. Association of TP53 haplotypes with somatic TP53 mutation in Caucasians

Haplotype + Any TP53 mutation
– Any TP53 mutation
OR (95% CI)

Frequency^* Frequency^*

Block I SNPs

TP53_34, TP53_01, TP53_66, TP53_16

    G-Arg-A-G 0.57 0.74 1

    C-Pro-G-A 0.17 0.13 1.80 (0.88-3.66)

    C-Pro-A-G 0.21 0.11 2.31 (1.18-4.52)

Block I SNPs plus TP53_11

TP53_34, TP53_01, TP53_66, TP53_16, TP53_11

    G-Arg-A-G-T 0.57 0.74 1

    C-Pro-G-A-T 0.16 0.13 1.71 (0.82-3.53)

    C-Pro-A-G-G 0.11 0.07 1.96 (0.85-4.50)

    C-Pro-A-G-T 0.10 0.04 3.15 (1.18-8.37)

Block II SNPs

TP53_11, TP53_14

    T-C 0.44 0.56 1

    T-T 0.44 0.36 1.53 (0.92-2.54)

    G-T 0.12 0.07 2.30 (0.94-5.60)

Combined SNPs associated with mutation

    TP53_34, TP53_01, TP53_16, TP53_14

    G-Arg-G-C 0.27 0.44 1

    G-Arg-G-T 0.29 0.30 1.48 (0.71-3.07)

    C-Pro-G-T 0.19 0.10 2.74 (1.25-6.05)

    C-Pro-A-C 0.12 0.11 1.64 (0.60-4.46)

^* Frequency of haplotypes in tumors with or without somatic TP53 mutation were calculated using haplo.cc. Associations determined for haplotypes $≥$ 5% frequency.

ORs and 95% CIs were calculated using haplo.glm assuming additive effects of haplotypes. Models were adjusted for age and pack-years of smoking.