CEBP -- Mechanic et al. 16 (2): 214 Table BL3

Table 3. Association of TP53 haplotypes with lung cancer in African Americans and Caucasians

Haplotype Case
Control
OR (95% CI)

Frequency^* Frequency^*

African Americans

    Block I SNPs

    TP53_01, TP53_65, TP53_66, TP53_16

        Arg-T-A-G 0.38 0.43 1

        Pro-T-G-A 0.24 0.27 0.92 (0.57-1.49)

        Pro-T-A-G 0.27 0.19 1.61 (0.98-2.64)

        Pro-C-A-G 0.08 0.10 1.10 (0.56-2.11)

    Block I SNPs plus TP53_11

    TP53_01, TP53_65, TP53_66, TP53_16, TP53_11

        Arg-T-A-G-T 0.37 0.42 1.0

        Pro-T-G-A-T 0.27 0.24 0.94 (0.58-1.52)

        Pro-T-A-G-G 0.17 0.10 1.94 (1.06-3.57)

        Pro-C-A-G-T 0.08 0.10 1.13 (0.58-2.19)

        Pro-T-A-G-T 0.11 0.09 1.40 (0.70-2.81)

Caucasians

    Block I SNPs

    TP53_34, TP53_01, TP53_66, TP53_16

        G-Arg-A-G 0.72 0.74 1

        C-Pro-G-A 0.12 0.11 1.00 (0.61-1.63)

        C-Pro-A-G 0.12 0.10 1.18 (0.79-1.75)

    Block I SNPs plus TP53_11

    TP53_34, TP53_01, TP53_66, TP53_16, TP53_11

        G-Arg-A-G-T 0.71 0.74 1

        C-Pro-G-A-T 0.12 0.12 1.17 (0.80-1.71)

        C-Pro-A-G-G 0.07 0.06 1.01 (0.61-1.63)

    Block II SNPs

    TP53_11, TP53_14

        T-C 0.56 0.58 1

        T-T 0.35 0.35 1.03 (0.80-1.33)

        G-T 0.08 0.07 1.01 (0.63-1.60)

^* Frequency of haplotypes in cases and controls (combined hospital and population controls) were determined using haplo.cc as described in Materials and Methods. Associations reported for haplotypes $≥$ 5% frequency.

ORs and 95% CIs were calculated using haplo.glm adjusted for age, smoking status, (never, former, and current), and pack-years of smoking (continuous) assuming additive effects of haplotypes.