Table 2. Association of TP53 polymorphisms with lung cancer in African Americans and Caucasians
| Genotype |
African American
|
Caucasian
|
| Case, n (%) |
Control, n (%) |
OR (95% CI)* |
Case, n (%) |
Control, n (%) |
OR (95% CI)* |
|
| TP53_34 IVS2 +38 |
| G/G |
30 (27) |
51 (27) |
1 |
148 (51) |
187 (58) |
1 |
| G/C |
55 (49) |
98 (52) |
0.96 (0.51-1.81) |
126 (44) |
119 (37) |
1.34 (0.94-1.92) |
| C/C |
28 (25) |
40 (21) |
1.22 (0.57-2.59) |
15 (5) |
19 (6) |
0.90 (0.42-1.93) |
|
|
|
Ptrend = 0.63 |
|
|
Ptrend = 0.36 |
| G/C + C/C |
83 (74) |
138 (73) |
1.03 (0.57-1.88) |
141 (49) |
138 (43) |
1.28 (0.90-1.80) |
| TP53_01 Arg72Pro |
| Arg/Arg |
16 (14) |
46 (23) |
1 |
166 (54) |
193 (58) |
1 |
| Arg/Pro |
57 (50) |
83 (42) |
2.48 (1.16-5.27) |
125 (41) |
122 (36) |
1.23 (0.86-1.76) |
| Pro/Pro |
42 (37) |
67 (34) |
1.84 (0.85-3.99) |
16 (5) |
20 (6) |
0.87 (0.41-1.84) |
|
|
|
Ptrend = 0.25 |
|
|
Ptrend = 0.59 |
| Arg/Pro + Pro/Pro |
99 (87) |
150 (76) |
2.16 (1.07-4.36) |
141 (46) |
142 (39) |
1.18 (0.84-1.66) |
| TP53_65 IVS4 –125 |
| T/T |
97 (85) |
159 (83) |
1 |
269 (92) |
304 (94) |
1 |
| T/C |
15 (13) |
30 (16) |
0.96 (0.45-2.02) |
25 (8) |
21 (6) |
1.48 (0.78-2.82) |
| C/C |
2 (2) |
3 (2) |
1.82 (0.26-12.6) |
0 (0) |
0 (0) |
ND |
|
|
|
Ptrend = 0.81 |
|
|
|
| T/C + C/C |
17 (15) |
33 (18) |
1.02 (0.50-2.08) |
25 (8) |
21 (6) |
1.48 (0.78-2.82) |
| TP53_66 IVS4 –91 |
| A/A |
65 (58) |
101 (53) |
1 |
225 (77) |
254 (78) |
1 |
| A/G |
39 (35) |
75 (40) |
0.69 (0.39-1.22) |
62 (21) |
68 (21) |
1.17 (0.77-1.78) |
| G/G |
8 (7) |
13 (7) |
0.97 (0.33-2.84) |
7 (2) |
5 (2) |
1.08 (0.31-3.76) |
|
|
|
Ptrend = 0.41 |
|
|
Ptrend = 0.51 |
| A/G + G/G |
47 (42) |
88 (47) |
0.73 (0.42-1.25) |
69 (23) |
73 (23) |
1.16 (0.77-1.74) |
| TP53_16 IVS6 +62 |
| G/G |
62 (55) |
97 (51) |
1 |
217 (75) |
243 (75) |
1 |
| G/A |
43 (38) |
75 (39) |
0.75 (0.43-1.33) |
68 (23) |
75 (23) |
1.12 (0.74-1.68) |
| A/A |
8 (7) |
18 (9) |
0.55 (0.20-1.50) |
6 (2) |
5 (2) |
0.93 (0.25-3.41) |
|
|
|
Ptrend = 0.17 |
|
|
Ptrend = 0.69 |
| G/A + A/A |
51 (45) |
93 (48) |
0.71 (0.41-1.22) |
74 (25) |
80 (25) |
1.10 (0.74-1.64) |
| TP53_11 IVS7 +92 |
| T/T |
78 (69) |
155 (82) |
1 |
247 (85) |
281 (86) |
1 |
| T/G |
31 (27) |
30 (16) |
2.31 (1.19-4.47) |
42 (14) |
45 (14) |
0.91 (0.56-1.49) |
| G/G |
4 (4) |
4 (2) |
1.49 (0.27-8.19) |
3 (1) |
1 (0) |
1.97 (0.19-20.6) |
|
|
|
Ptrend = 0.03 |
|
|
Ptrend = 0.91 |
| T/G + G/G |
35 (31) |
34 (18) |
2.20 (1.17-4.14) |
45 (15) |
46 (14) |
0.94 (0.58-1.52) |
| TP53_14 1474 3'STP |
| C/C |
45 (40) |
81 (43) |
1 |
92 (32) |
116 (36) |
1 |
| C/T |
48 (43) |
76 (41) |
0.99 (0.55-1.77) |
144 (50) |
147 (45) |
1.17 (0.80-1.72) |
| T/T |
19 (17) |
30 (16) |
1.13 (0.53-2.42) |
55 (19) |
63 (19) |
1.02 (0.63-1.66) |
|
|
|
Ptrend = 0.80 |
|
|
Ptrend = 0.81 |
| C/T + T/T |
67 (60) |
106 (57) |
1.03 (0.60-1.77) |
199 (69) |
210 (64) |
1.12 (0.78-1.62) |
| TP53_15 1846 3'STP |
| C/C |
104 (92) |
164 (86) |
1 |
201 (70) |
230 (71) |
1 |
| C/T |
9 (8) |
25 (13) |
0.47 (0.19-1.18) |
82 (28) |
91 (28) |
1.04 (0.71-1.53) |
| T/T |
0 (0) |
1 (1) |
ND |
6 (2) |
5 (2) |
1.09 (0.29-4.03) |
|
|
|
Ptrend = 0.10 |
|
|
Ptrend = 0.81 |
| C/T + T/T |
9 (8) |
26 (14) |
0.47 (0.19-1.17) |
88 (30) |
96 (30) |
1.05 (0.72-1.52) |
| TP53_71 1855 3' STP |
| A/A |
88 (77) |
163 (86) |
1 |
264 (90) |
296 (92) |
1 |
| A/G |
26 (23) |
26 (14) |
1.63 (0.82-3.24) |
28 (10) |
25 (8) |
1.19 (0.64-2.21) |
| G/G |
0 (0) |
1 (1) |
ND |
0 (0) |
0 (0) |
ND |
|
|
|
Ptrend = 0.19 |
|
|
|
| A/G + G/G |
26 (23) |
27 (15) |
1.61 (0.81-3.19) |
28 (10) |
25 (8) |
1.19 (0.64-2.21) |
|
Abbreviation: ND, not determined.
* Adjusted for age, smoking status (never, former, and current), and pack-years of smoking (continuous).